Results 31 to 40 of about 536,225 (354)
BMJ Open, 2019 Introduction BRCA1/2 gene mutations increase risk of breast and/or ovarian cancer and may have implications for reproductive health. Indirect biomarkers of the ovarian primordial follicle pool (anti-Müllerian hormone (AMH)) and one small study in female ...
Amy Louise Winship +4 more
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Metabolic cooperation in the ovarian follicle.
Physiological Research, 2019 Granulosa cells (GCs) are somatic cells essential for establishing and maintaining bi-directional communication with the oocytes. This connection has a profound importance for the delivery of energy substrates, structural components and ions to the ...
J. Fontana +4 more
semanticscholar +1 more source
Advances in human primordial follicle activation and premature ovarian insufficiency.
Reproduction, 2020 In women, the non-growing population of follicles that comprise the ovarian reserve is determined at birth and serves as the reservoir for future fertility.
E. Ford +4 more
semanticscholar +1 more source
Granulosa Cell Apoptosis in the Ovarian Follicle—A Changing View
Frontiers in Endocrinology, 2018 Recent studies challenge the previous view that apoptosis within the granulosa cells of the maturing ovarian follicle is a reflection of aging and consequently a marker for poor quality of the contained oocyte.
Sheena L. P. Regan +5 more
semanticscholar +1 more source
Ovarian Follicle Development Requires Smad3 [PDF]
Molecular Endocrinology, 2004 AbstractSmad3 is an important mediator of the TGFβ signaling pathway. Interestingly, Smad3-deficient (Smad3−/−) mice have reduced fertility compared with wild-type (WT) mice. To better understand the molecular mechanisms underlying the reduced fertility in Smad3−/− animals, this work tested the hypothesis that Smad3 deficiency interferes with three ...
Dragana, Tomic +5 more
openaire +2 more sources
Female reproductive aging is master-planned at the level of ovary.
PLoS ONE, 2014 The ovary receives a finite pool of follicles during fetal life. Atresia remains the major form of follicular expenditure at all stages since development of ovary.
Sayani Banerjee +4 more
doaj +1 more source
Is there a relationship between ovarian reserve and blood groups in infertile patients?
Gynecology Obstetrics & Reproductive Medicine, 2019 Objective: Evaluation of ovarian reserve in infertile patients had become an important concept in assisted reproductive techniques (ART) success work-up. Recent studies reported an association between blood type and ovarian reserve. Therefore, the aim of
Ozgur Kan +6 more
doaj +1 more source
Veterinary Sciences, 2023 The objectives of this study were (1) to investigate the distribution of large (≥10 mm) follicle numbers during the estrous cycle and (2) to compare the timing of the estrus expression period after the ovarian examination between cows with one large ...
Ryotaro Miura +9 more
doaj +1 more source
TMCO1 is essential for ovarian follicle development by regulating ER Ca2+ store of granulosa cells
Cell Death and Differentiation, 2018 TMCO1 (transmembrane and coiled-coil domains 1) is an endoplasmic reticulum (ER) transmembrane protein that actively prevents Ca2+ stores from overfilling. To characterize its physiological function(s), we generated Tmco1−/− knockout (KO) mice.
Zhongshuai Sun +12 more
semanticscholar +1 more source
In vitro differentiation of human embryonic stem cells into ovarian follicle-like cells
Nature Communications, 2017 Understanding the unique mechanisms of human oogenesis necessitates the development of an in vitro system of stem cell differentiation into oocytes. Specialized cell types and organoids have been derived from human pluripotent stem cells in vitro, but ...
Dajung Jung +12 more
semanticscholar +1 more source