Results 21 to 30 of about 107,481 (307)

Evaluation of an alternative heterotopic transplantation model for ovarian tissue to test pharmaceuticals improvements for fertility restoration

Reproductive Biology and Endocrinology, 2022
Background Ovarian tissue cryopreservation and transplantation (OTCTP) is currently the main option available to preserve fertility in prepubertal patients undergoing aggressive cancer therapy treatments.
Carmen Terren, Jules Bindels, Michelle Nisolle, Agnès Noël, Carine Munaut   +4 more
doaj   +1 more source

Methylglyoxal-dependent glycative stress and deregulation of SIRT1 functional network in the ovary of PCOS mice [PDF]

, 2020
Advanced glycation end-products (AGEs) are involved in the pathogenesis and consequences of polycystic ovary syndrome (PCOS), a complex metabolic disorder associated with female infertility.
Amicarelli, F, Cristiano, L, D'Alessandro, AM, Emidio, GD, Falone, S, Nottola, S, Palmerini, MG, Placidi, M, Rea, F, Rossi, G, Tatone, C   +10 more
core   +1 more source

Senataxin: A New Guardian of the Female Germline Important for Delaying Ovarian Aging

Frontiers in Genetics, 2021
Early decline in ovarian function known as premature ovarian aging (POA) occurs in around 10% of women and is characterized by a markedly reduced ovarian reserve.
Hayden A. Homer
doaj   +1 more source

Texture profile analysis reveals a stiffer ovarian cortex after testosterone therapy : a pilot study [PDF]

, 2019
Purpose: The importance of the surrounding ovarian stromal cells and extracellular matrix in the development and maturation of follicles has recently gained attention.
De Roo, Chloë, De Sutter, Petra, Declercq, Heidi, T'Sjoen, Guy, Tilleman, Kelly, Vercruysse, Chris, Weyers, Steven   +6 more
core   +2 more sources

Effects of hypoxia-preconditioned HucMSCs on neovascularization and follicle survival in frozen/thawed human ovarian cortex transplanted to immunodeficient mice

Stem Cell Research & Therapy, 2022
Background The massive loss of follicles in the early stage of ovarian tissue transplantation is considered a significant restriction to the efficacy of ovarian tissue cryopreservation (OTC) and transplantation (OT).
Jiaojiao Cheng, Xiangyan Ruan, Yanglu Li, Juan Du, Fengyu Jin, Muqing Gu, Qi Zhou, Xin Xu, Yu Yang, Husheng Wang, Alfred Otto Mueck   +10 more
doaj   +1 more source

Do BRCA1 and BRCA2 gene mutation carriers have a reduced ovarian reserve? Protocol for a prospective observational study

BMJ Open, 2019
Introduction BRCA1/2 gene mutations increase risk of breast and/or ovarian cancer and may have implications for reproductive health. Indirect biomarkers of the ovarian primordial follicle pool (anti-Müllerian hormone (AMH)) and one small study in female ...
Amy Louise Winship, Chris Willson, Karl R Hansen, Karla J Hutt, Martha Hickey   +4 more
doaj   +1 more source

Human Ovarian Follicles Xenografted in Immunoisolating Capsules Survive Long Term Implantation in Mice

Frontiers in Endocrinology, 2022
Female pediatric cancer survivors often develop Premature Ovarian Insufficiency (POI) owing to gonadotoxic effects of anticancer treatments. Here we investigate the use of a cell-based therapy consisting of human ovarian cortex encapsulated in a poly ...
Margaret A. Brunette, Hadrian M. Kinnear, Hadrian M. Kinnear, Prianka H. Hashim, Colleen L. Flanagan, James R. Day, Marilia Cascalho, Marilia Cascalho, Vasantha Padmanabhan, Vasantha Padmanabhan, Ariella Shikanov, Ariella Shikanov, Ariella Shikanov   +12 more
doaj   +1 more source

Ovarian Follicle Development Requires Smad3 [PDF]

Molecular Endocrinology, 2004
AbstractSmad3 is an important mediator of the TGFβ signaling pathway. Interestingly, Smad3-deficient (Smad3−/−) mice have reduced fertility compared with wild-type (WT) mice. To better understand the molecular mechanisms underlying the reduced fertility in Smad3−/− animals, this work tested the hypothesis that Smad3 deficiency interferes with three ...
Dragana, Tomic, Kimberly P, Miller, Hilary A, Kenny, Teresa K, Woodruff, Patricia, Hoyer, Jodi A, Flaws   +5 more
openaire   +2 more sources

Is there a relationship between ovarian reserve and blood groups in infertile patients?

Gynecology Obstetrics & Reproductive Medicine, 2019
Objective: Evaluation of ovarian reserve in infertile patients had become an important concept in assisted reproductive techniques (ART) success work-up. Recent studies reported an association between blood type and ovarian reserve. Therefore, the aim of
Ozgur Kan, Umit Gorkem, Aysegul Alkilic, Deniz Taskiran, Ozgur Kocak, Engin Yildirim, Cihan Togrul   +6 more
doaj   +1 more source

Primordial follicular assembly in humans : revisited [PDF]

, 2009
Peer ...
A. Maheshwari, Baker, Donovan, Gumienny, Konishi, P. A. Fowler, Pinkerton, Satoh, Vaskivuo   +8 more
core   +1 more source