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Aging conundrum: A perspective for ovarian aging
Frontiers in Endocrinology, 2022 Progressive loss of physiological integrity and accumulation of degenerative changes leading to functional impairment and increased susceptibility to diseases are the main features of aging. The ovary, the key organ that maintains female reproductive and
Jiachen Wu +5 more
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Mitochondrial dysfunction in ovarian aging [PDF]
Chinese Medical Journal. Mitochondria serve as multifunctional powerhouses within cells, coordinating essential biological activities that are critical for cell viability, including material metabolism, signal transduction, and the maintenance of homeostasis.
Shuxin Ma +3 more
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The Role of Oxidative Stress and Natural Antioxidants in Ovarian Aging
Frontiers in Pharmacology, 2021 The ovarian system comprises vital organs in females and is of great significance for the maintenance of reproductive potential and endocrine stability. Although complex pathogenesis undoubtedly contributes to ovarian aging, increasing attention is being
Liuqing Yang +8 more
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Ovarian Aging: Mechanisms, Age‐Related Disorders, and Therapeutic Interventions [PDF]
MedCommOvarian aging is a fundamental process in female reproductive biology with broad implications for overall health and aging. As global populations age, understanding its mechanisms and systemic effects has gained urgent clinical relevance.
Xingyu Liu +4 more
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Mesenchymal stem cells and their promise in reversing ovarian aging [PDF]
Journal of Ovarian ResearchOvarian aging is accompanied by a decline in the quantity and quality of follicles, leading to reduced fertility. Ovarian aging encompasses natural aging due to DNA damage, telomere attrition, and mitochondrial dysfunction, as well as a pathological ...
Dongmei Yao +10 more
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FSHR-targeting tetrahedral DNA frameworks ameliorate ovarian aging through oxidative stress elimination [PDF]
Journal of NanobiotechnologyOvarian aging, characterized by declining ovarian reserve, is a pacemaker of aging in the female body. Oxidative stress leads to apoptosis, mitochondrial dysfunction, inflammation, and telomere shortening, accelerating ovarian aging.
Yun Dai +12 more
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Role and mechanisms of plant polyphenols in ovarian aging [PDF]
Journal of Ovarian ResearchThe ovary is a vital organ in female animals, playing a crucial role in regulating reproductive and endocrine functions. Ovarian aging is characterized by declining oocyte quality and ovarian reserve quantity, ultimately leading to infertility and ...
Haojie Gong +4 more
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Current understanding of ovarian aging [PDF]
Science China Life Sciences, 2012 The reproductive system of human female exhibits a much faster rate of aging than other body systems. Ovarian aging is thought to be dominated by a gradual decreasing numbers of follicles, coinciding with diminished quality of oocytes. Menopause is the final step in the process of ovarian aging.
Qinghua Shi, Shi Qinghua
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Single-cell dissection of regulated cell death dynamics in ovarian aging [PDF]
Journal of Ovarian ResearchBackground Ovarian aging drives declining fertility, premature menopause, and systemic age-related diseases. Multiple different types of regulated cell death (RCD) pathways have been identified and play integral roles in diverse physiological and ...
Qianyu Zhang +6 more
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Ovarian Stem Cell Nests in Reproduction and Ovarian Aging [PDF]
Cellular Physiology and Biochemistry, 2017 The fixed primordial follicles pool theory, which monopolized reproductive medicine for more than one hundred years, has been broken by the discovery, successful isolation and establishment of ovarian stem cells.
Haifeng Ye +11 more
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