The influence of the gut microbiome on ovarian aging
Gut MicrobesOvarian aging occurs prior to the aging of other organ systems and acts as the pacemaker of the aging process of multiple organs. As life expectancy has increased, preventing ovarian aging has become an essential goal for promoting extended reproductive ...
Feiling Huang +6 more
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Quantitative proteomic analysis of pathological and physiological ovarian aging: model evaluation, molecular mechanisms, and identification of early biomarkers and therapeutic targets [PDF]
Journal of Ovarian ResearchObjectives Ovarian aging is considered the “pacemaker” and “biological clock” of systemic female aging, with early manifestations that are often insidious.
Mengying Bai +7 more
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DNMT/TET Imbalance and Network-Level DNA Methylation Remodeling in Ovarian Aging: Mechanistic Perspectives [PDF]
BiologyReproductive aging is characterized by progressive decline in ovarian reserve, reduced oocyte competence, and impaired endocrine coordination. Although these phenotypic changes are well documented, the molecular mechanisms that integrate aging-associated
Miaofang Lin +6 more
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The impact of mitochondrial dysfunction on ovarian aging [PDF]
Journal of Translational MedicineImportance Ovarian aging has become a focal point in current research on female aging and refers to the gradual decline in ovarian function as women age. Numerous factors influence ovarian aging, among which mitochondrial function is one because it plays
Xiaoyue Zhang, Ling Zhang, Wenpei Xiang
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Mitochondrial Dysfunction and Ovarian Aging
Endocrinology, 2020 Abstract As women delay childbearing because of demographic and socioeconomic trends, reproductive aging and ensuing ovarian dysfunction become increasingly more prevalent causes of infertility. Age-related decline in fertility is characterized by both quantitative and qualitative deterioration of the ovarian reserve.
Emre Seli, Seli Emre
exaly +4 more sources
Preventing ovarian aging: from redox-targeted strategies to extracellular vesicle-based therapies [PDF]
Frontiers in AgingOvarian aging is increasingly recognized as a dynamic and modifiable process influenced by oxidative stress, mitochondrial dysfunction, and chronic inflammation.
Chiara Camerano Spelta Rapini +9 more
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Frontiers in Endocrinology, 2023 The ovarian microenvironment is critical for follicular development and oocyte maturation. Maternal conditions, including polycystic ovary syndrome (PCOS), endometriosis, and aging, may compromise the ovarian microenvironment, follicular development, and
Makoto Orisaka +8 more
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Oviductus Ranae alleviates D-galactose-induced ovarian aging by inhibiting ferroptosis and regulating the GPX4/ACSL4 pathway [PDF]
Journal of Ovarian ResearchBackground Ovarian dysfunction caused by aging restricts female reproductive capacity and causes age-related health problems. Ferroptosis is an important mode of cell death during accelerated aging.
Xiaomei Ling +9 more
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Mesenchymal stem cells derived extracellular vesicles ameliorate ovarian aging through inhibiting LGALS3BP/NF-κB induced inflammation [PDF]
Journal of Ovarian ResearchBackgroud Ovarian aging can lead to early menopause, infertility, and even premature senility in female patients, seriously impairing the quality of life. Unfortunatly, it is still lack of effective protection strategies against ovarian aging.
Shenghui Zhang +7 more
doaj +2 more sources
Mechanisms of ovarian aging [PDF]
Reproduction, 2021 Abstract Ovarian aging in women correlates with the progressive loss of both the number and quality of oocytes. When these processes occur early or are accelerated, their clinical correlates are diminished ovarian reserve and/or premature ovarian insufficiency. Both these conditions have important consequences for the reproductive and
Selena U Park +2 more
openaire +2 more sources