Results 101 to 110 of about 284,481 (355)

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

Histological Pattern Of Ovarian Neoplasms And Their Age Wise Distribution-Study Conducted At A Tertiary Care Hospital

Journal of Rawalpindi Medical College, 2019
Background: Ovarian cancer is the 6th most common cancer in females in USA. The purpose of this study is to determine the distribution of histopathological types of ovarian cancers in different age groups of females to provide an institutional experience.
Fazeelat Iftikhar, Hira Anum, Naghmana Iftikhar, Ammara Ijaz, Naima Gul   +4 more
doaj  

Multicentric peripheral T-cell lymphoma, bilateral granulosa cell tumor, and papillary ovarian adenocarcinoma in a female dog - case report

Arquivo Brasileiro de Medicina Veterinária e Zootecnia
The frequency of ovarian neoplasms in dogs is low, and these tumors are often underdiagnosed mainly due to nonspecific clinical signs. Multiple ovarian tumors are rarely described in dogs and can be of primary or secondary origin. Lymphomas, in turn, are
J.G. Wronski, K.Y.R. Nakagaki, E.A. Viscone, M.M. Nunes, G.D. Cassali   +4 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Constitutively active transforming growth factor β receptor 1 in the mouse ovary promotes tumorigenesis [PDF]

, 2016
Despite the well-established tumor suppressive role of TGFβ proteins, depletion of key TGFβ signaling components in the mouse ovary does not induce a growth advantage.
Bartholin, Laurent, Davis, Anna Jane, Gao, Yang, Li, Qinglei, Sansom, Owen, Vincent, David   +5 more
core   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

COMPARATIVE CHARACTERISTICS OF THE AVAILABLE LABORATORY TESTS AND THEIR COMBINATIONS USED IN DIFFERENTIAL DIAGNOSIS OF OVARIAN NEOPLASMS

Акушерство, гинекология и репродукция, 2018
n the case of a space-occupying lesion (SOL) of the ovary, it is up to the gynecologist to diagnose a possible malignancy and then decide upon further treatment strategy.
M. A. Egunova, I. G. Kutsenko
doaj   +1 more source

Prima segnalazione di un caso di tumore misto mulleriano dell’ovaio in un cane = First report of canine malignant mixed mullerian tumor of the ovary [PDF]

, 2008
Adenocarcinoma is the most represented histotype of primary ovarian neoplasms in aged bitch. In woman, adenocarcinomas are quite common, whereas mixed forms as carcinosarcomas, or malignant mixed mullerian tumors [MMMTs] are rarely reported. The aim of
Antuofermo, Elisabetta, Borzacchiello, Giuseppe, Bosincu, Luisanna, Burrai, Giovanni P., Cocco, Raffaella, Cossu Rocca, Paolo Alessandro, Meloni, Floriana, Pirino, Salvatore   +7 more
core  

Determining the date of diagnosis – is it a simple matter? The impact of different approaches to dating diagnosis on estimates of delayed care for ovarian cancer in UK primary care [PDF]

, 2009
Background Studies of cancer incidence and early management will increasingly draw on routine electronic patient records. However, data may be incomplete or inaccurate.
A Majeed, A Rosemary Tate, A Verdecchia, AB Ryerson, Alexander GR Martin, B Rachet, B Yawn, BA Goff, BA Goff, BA Goff, CR Bankhead, F Berrino, Jackie A Cassell, JMJ Kirwan, K Sikora, M Richards, ML Wynn, MP Coleman, R Horton, R Jones, R Lawrenson, Sarah R Anderson, SW Pascoe, Tarita Murray-Thomas, VL Allgar, VL Allgar, W Hamilton, W Hamilton   +27 more
core   +3 more sources