Results 221 to 230 of about 170,341 (384)

Sclero-Hyalinized Low-Grade Appendiceal Mucinous Neoplasm Clinically Mimicking an Ovarian Mass [PDF]

, 2022
Nnaemeka Thaddeus Onyishi, Anthony Jude Edeh, Ngozi Regina Dim   +2 more
openalex   +1 more source

Halofuginone Disrupted Collagen Deposition via mTOR‐eIF2α‐ATF4 Axis to Enhance Chemosensitivity in Ovarian Cancer

Advanced Science, EarlyView.
COL1A1, a major component of ECM, contributes to chemoresistance and poor prognosis in ovarian cancer. Halofuginone (HF) attenuates CAF‐secreted COL1A1 through mTOR‐eIF2α‐ATF4 axis. Notably, HF disrupts collagen deposition to form the looser ECM and facilitates CD8+ T cell infiltration, partially via M2‐M1 macrophage polarization to enhance ...
Wenxin Li, Yenan Wu, Yanan Zhang, Wenyan Gao, Xin Li, Haixia Luo, Mengmeng Lu, Zhihua Liu, Aiping Luo   +8 more
wiley   +1 more source

Constitutive expression of progesterone receptor isoforms promotes the development of hormone-dependent ovarian neoplasms. [PDF]

Sci Signal, 2020
Wetendorf M, Li R, Wu SP, Liu J, Creighton CJ, Wang T, Janardhan KS, Willson CJ, Lanz RB, Murphy BD, Lydon JP, DeMayo FJ.   +11 more
europepmc   +1 more source

A Recurrent Mucinous Neoplasm Originating From an Ovarian Mucinous Cystadenoma After an Adnexectomy As the First Procedure: A Case Report [PDF]

, 2022
Satoshi Ohira, Akiko Hayashi, Reika Kitano, Kyoko Tanaka, Fumiaki Kitamura   +4 more
openalex   +1 more source

Nuclear‐Localized BCKDK Facilitates Homologous Recombination Repair to Support Breast Cancer Progression and Therapy Resistance

Advanced Science, EarlyView.
Under DNA damage, tumor cells rely on efficient DNA repair for survival and therapy resistance. This study has demonstrated that BCKDK localizes to breast cancer cell nuclei, where it binds to and phosphorylates RNF8, thereby blocking ubiquitin‐mediated degradation of RAD51 and enhancing HRR. A selective BCKDK inhibitor synergizes with clinical agents,
Haiying Liu, Jiaqian Feng, Tingting Pan, Pinggen Zhang, Ling Ye, Zetan Jiang, Zilong Zhou, Qiankun Mao, Jian Li, Xinyi Yang, Ping Gao, De Huang, Huafeng Zhang   +12 more
wiley   +1 more source

Targeted deep sequencing of mucinous ovarian tumors reveals multiple overlapping RAS-pathway activating mutations in borderline and cancerous neoplasms [PDF]

, 2015
Robertson Mackenzie, Stefan Kommoss, Boris Winterhoff, Benjamin R. Kipp, Joaquín J. García, Jesse S. Voss, Kevin C. Halling, Anthony N. Karnezis, Janine Senz, Winnie Yang, Elena‐Sophie Prigge, Miriam Reuschenbach, Magnus von Knebel Doeberitz, Blake C. Gilks, David G. Huntsman, Jamie N. Bakkum‐Gamez, Jessica N. McAlpine, Michael S. Anglesio   +17 more
openalex   +1 more source

LncRNA‐MEG3 Regulates Muscle Mass and Metabolic Homeostasis by Facilitating SUZ12 Liquid–Liquid Phase Separation

Advanced Science, EarlyView.
This study has identified lncRNA‐MEG3 as a key regulator of muscle mass, promoting slow‐twitch muscle fibers and preventing muscle atrophy. By stabilizing the SUZ12/PRC2 complex through liquid–liquid phase separation (LLPS), lncRNA‐MEG3 influences mitochondrial function and lipid metabolism.
Yilong Yao, Chao Yan, Haibo Huang, Shilong Wang, Jiaying Li, Yun Chen, Xiaolu Qu, Qi Bao, Lingna Xu, Yuanyuan Zhang, Danyang Fan, Xia He, Yanwen Liu, Yongsheng Zhang, Yalan Yang, Zhonglin Tang   +15 more
wiley   +1 more source

Use of tumor markers to distinguish endometriosis-related ovarian neoplasms from ovarian endometrioma. [PDF]

Int J Gynecol Cancer, 2020
Shinmura H, Yoneyama K, Harigane E, Tsunoda Y, Fukami T, Matsushima T, Takeshita T.   +6 more
europepmc   +1 more source

Overview on Screening and Prevalence of Ovarian Neoplasms in Saudi Arabia [PDF]

, 2022
Hesham Mohammad Hamad Morcy, Nouf Dhaifallah A Almatrafi, Amal Abdulelah A Bedaiwi, Atheer Abdullah M Almijlad, Shahad Khalid A Bedaiwi, Norah Abdullah N Alsharif   +5 more
openalex   +1 more source

LRRC4 Deficiency Drives Premature Ovarian Insufficiency by Disrupting Metabolic Homeostasis in Granulosa Cells

Advanced Science, EarlyView.
LRRC4 deficiency disrupts the metabolic homeostasis of mitochondrial aerobic respiration and glycolysis during GC differentiation by inhibiting the ubiquitination‐mediated degradation of YAP, which ultimately leads to POI. These findings reveal the novel molecular etiology of POI and provide a promising target for prevention and treatment.
Yujie Shang, Yunjun Li, Di Han, Kun Deng, Wei Gao, Minghua Wu   +5 more
wiley   +1 more source