Results 121 to 130 of about 624,533 (255)

A Multi‐Targeting Chimeric Antigen Receptor‐T Cell Platform to Overcome Antigen Heterogeneity in the Treatment of Non‐Small Cell Lung Cancer

Advanced Science, EarlyView.
A dual‐transmembrane Bicephali CAR‐T platform simultaneously targets CD276 and NKG2D ligands to address antigen heterogeneity in non‐small cell lung cancer. By improving immune synapse formation, mitochondrial fitness, antioxidant capacity, and stem‐like persistence, this design enhances durable tumor control and provides a versatile strategy to ...
Lina Wang, Yanlei Zhang, Shuixiu Peng, Chenchen Hou, Huaqi Guo, Tianyu Zhou, Alex H. Chang, Lifeng Yan, Weining Xiong   +8 more
wiley   +1 more source

Efficacy of Acupuncture for Diminished Ovarian Reserve: A Randomized Controlled Trial Protocol [PDF]

Yuemeng Zhao,1,2,* Liying Liu,1,* Xinyue Tao,1,* Di Gan,1,3 Yuanyuan Lai,1 Chunhui Tian,1 Lei Huang,1 Yufei Huang,1 Jie Yang1 1College of Acupuncture and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province ...
Lai Y, Yang J, Liu L, Huang Y, Tao X, Tian C, Huang L, Zhao Y, Gan D   +8 more
core  

Galactokinase 1 Positively Regulates Mitochondrial Respiration by Phosphorylating TIMM13 as a Protein Kinase

Advanced Science, EarlyView.
GALK1 acts as a protein kinase beyond the phosphorylation of galactose. GALK1 phosphorylates TIMM13 at Y73 in the cytoplasm. This phosphorylation prevents premature oxidative folding of TIMM13 and ensures its entrance into the intermembrane space of mitochondrion, positively regulating mitochondrial respiration.
Chang Woo Ko, Dongyoon Shin, Junho Park, June Huh, Youngsoo Kim, Jong‐Wan Park   +5 more
wiley   +1 more source

European guidelines from the EHTG and ESCP for Lynch syndrome: an updated third edition of the Mallorca guidelines based on gene and gender

BJS (British Journal of Surgery), EarlyView., 2020
Recommendations for clinical and molecular identification of LS, surgical and endoscopic management of LS‐associated colorectal cancer and preventive measures for cancer were produced. The emphasis was on surgical and gastroenterological aspects of the cancer spectrum.
T. T. Seppälä, A. Latchford, I. Negoi, A. Sampaio Soares, R. Jimenez‐Rodriguez, L. Sánchez‐Guillén, D. G. Evans, N. Ryan, E. J. Crosbie, M. Dominguez‐Valentin, J. Burn, M. Kloor, M. von Knebel Doeberitz, F. J. B. van Duijnhoven, P. Quirke, J. R. Sampson, P. Møller, G. Möslein, on behalf of the European Hereditary Tumour Group (EHTG) and European Society of Coloproctology (ESCP)   +18 more
wiley   +1 more source

Reproductive Endocrine Mechanisms Regulating Ovarian Reserve in Polyendocrine Metabolic Ovarian Syndrome

This paper investigates the reproductive endocrine mechanisms of the ovarian reserve in polyendocrinopathy, autoimmune polyglandular syndrome type 1 (APCOS), which is a new term for polycystic ovary syndrome (PCOS). Rather than viewing ovarian reserve as
Yixin Feng
core   +1 more source

Mitochondrial Localization of Cx26 Promotes Colorectal Cancer Malignancy and Exposes a Fatal Vulnerability to Drug Targeting

Advanced Science, EarlyView.
Mitochondrial localization of Cx26 emerges as a double‐edged sword in colorectal cancer. PIMT‐mediated methylation of Cx26 promotes its mitochondrial localization and stability. Mitochondrial Cx26 then facilitates ER‐mitochondria communication and Ca2+ signaling, thereby promoting metastatic progression. Bortezomib exploits this malignant adaptation by
Jie Wang, Lu Chen, Jia Qin, Xiaoning Wang, Sunlan Ye, Ning An, Mei Bai, Yan Shen, Xuefeng Wu, Qiang Xu   +9 more
wiley   +1 more source

Anti-Müllerian hormone versus antral follicle count as first-choice biomarkers in a low-resource setting: A cross-sectional study in Kumasi, Ghana

Journal of International Medical Research
Objective To evaluate age-related variations in ovarian reserve among women in Kumasi, Ghana, and determine the preferred first-choice biomarker, either anti-Müllerian hormone or antral follicle count, in a low-resource setting. Methods A cross-sectional
Francis Jojo Moses Kwadzo Damalie, Kweku Bedu-Addo, Charles Mawunyo Senaya, Edward Tieru Dassah, Alexander Anning, Phillip Kweku Baidoo, Kofi Owusu-Daaku, Patrick Addo-Fordjour   +7 more
doaj   +1 more source

Account of the jollification upon the news of peace in 1815

Account of celebrations after War of 1812Cleveland, Ohio and the Western Reserve Digital Text ...
(Creatorcre)
core  

Is ovarian reserve related to blood type?

Is ovarian reserve related to blood type? In recent years, several reports have pointed to a novel association between blood type ABO and a number of processes related to female infertility, including diminished ovarian reserve (DOR), poor response to ...
Bellver Pradas, José
core   +1 more source

One‐Step Induction of Oogonia‐Like and Pro‐Spermatogonia‐Like Cells From Porcine Pluripotent Stem Cells

Advanced Science, EarlyView.
This study established a one‐step method inducing pro‐spermatogonia‐like (activating SOX17) and oogonia‐like (activating SOX17/TFAP2C) cells from porcine pgEpiSCs with a NANOS3‐tdTomato reporter. EGF activates the core PGC program and supports survival; BMP4 further induces NANOS3 and DDX4 expression; IWR1 enhances PGCLC efficiency by suppressing ...
Pengcheng He, Liang Zhong, Tianzhi Chen, Yaxuan Yan, Xinze Chen, Runbo Li, Yingjie Wang, Yadi Teng, Minglei Zhi, Meng Wang, Jinying Zhang, Fan Zhao, Dengfeng Gao, Suying Cao, Jianyong Han   +14 more
wiley   +1 more source