Results 161 to 170 of about 581,549 (298)

Targeted Lysosomal Degradation of Extracellular and Membrane Proteins: From Receptor Hijacking to Programmable Endolysosomal Routing

Advanced Science, EarlyView.
Targeted chimeric degraders engage extracellular or membrane proteins and endocytosable cell‐surface receptors, forming ternary complexes that induce receptor‐mediated internalization. Following endocytosis, post‐endocytic sorting—not internalization alone—determines target fate.
Ke Liu, Xiyan Wang, Xiaozhen Liu, Chaoqi He, Da Qian, Xuli Meng, Liquan Zhu   +6 more
wiley   +1 more source

Developing anti-Müllerian hormone as an ovarian reserve biomarker. [PDF]

Mol Hum Reprod
Fauser BCJM.
europepmc   +1 more source

SOX30 Facilitates Triple‐Negative Breast Cancer Metastasis via TNFR2–NF‐κB Signaling and Tumor Microenvironment Remodeling

Advanced Science, EarlyView.
SOX30 drives triple‐negative breast cancer (TNBC) metastasis through a dual mechanism: direct activation of the TNFR2/NF‐κB signaling cascade and subsequent CCL20‐mediated recruitment of tumor‐associated macrophages (TAMs) into the tumor microenvironment.
Pingping Gao, Na Sun, Ning Yang, Tingting Zhao, Rui Fu, Zhenyu Wu, Yuqin Zhou, Xuanni Tan, Yi Zhang, Fei Han, Xiaowei Qi   +10 more
wiley   +1 more source

Three-dimensional mapping of intact ovaries reveals the aging dynamics of the ovarian reserve. [PDF]

Nat Aging
D'Angelo A, Franco-Barranco D, Musy M, Duran JM, Sharpe J, Stroustrup N, Carreras IA, Böke E.   +7 more
europepmc   +1 more source

Toward Predictable Nanomedicine: Current Forecasting Frameworks for Nanoparticle–Biology Interactions

Advanced Intelligent Discovery, EarlyView.
Predictive models successfully screen nanoparticles for toxicity and cellular uptake. Yet, complex biological dynamics and sparse, nonstandardized data limit their accuracy. The field urgently needs integrated artificial intelligence/machine learning, systems biology, and open‐access data protocols to bridge the gap between materials science and safe ...
Mariya L. Ivanova, Michael Nicholls, Nicola Russo, Gueorgui Mihaylov, Konstantin Nikolic   +4 more
wiley   +1 more source

Clinically Informed Intelligent Classification of Ovarian Cancer Cells by Label‐Free Holographic Imaging Flow Cytometry

Advanced Intelligent Systems, Volume 7, Issue 3, March 2025.
Quantitative phase maps of single cells recorded in flow cytometry modality feed a hierarchical architecture of machine learning models for the label‐free identification of subtypes of ovarian cancer. The employment of a priori clinical information improves the classification performance, thus emulating the clinical application of liquid biopsy during ...
Daniele Pirone, Beatrice Cavina, Daniele Gaetano Sirico, Martina Mugnano, Vittorio Bianco, Lisa Miccio, Anna Myriam Perrone, Anna Maria Porcelli, Giuseppe Gasparre, Ivana Kurelac, Pasquale Memmolo, Pietro Ferraro   +11 more
wiley   +1 more source

The Impact of Bilateral Salpingectomy on Ovarian Reserve: A Prospective Analysis of Hormonal, Ultrasound and Clinical Correlations. [PDF]

Med Sci (Basel)
Radu T, Mar M, Gliga M, Marginean C.
europepmc   +1 more source

Cancer Incidence Among Swedish Seafarers Between 1985 and 2020

American Journal of Industrial Medicine, EarlyView.
ABSTRACT Background Several studies from different countries have shown that merchant seafarers have an increased cancer risk compared to the general population. The aim of this study was to provide updated information on cancer incidence in a cohort of Swedish seafarers.
Maria Wallin, Helena P. Eriksson, Karl Forsell, Eva Andersson   +3 more
wiley   +1 more source

Association of Serum Phoenixin-14 and Phoenixin-20 with Diminished Ovarian Reserve. [PDF]

J Clin Med
Akin OD, Misirlioglu NF, Karalok MH, Dönmez YÇ, Simsek G, Alacam H, Uzun H.   +6 more
europepmc   +1 more source

Account of early settlers in the Western Reserve, including biographical sketches, a chronology, and notes on the towns of Mayfield Brecksville, Solon, and Rockport.

General, account of John Barr of early settlers in the Western Reserve, including biographical sketches, a chronology, and notes on the towns of Mayfield Brecksville, Solon, and Rockport, 1846?Cleveland, Ohio and the Western Reserve Digital Text ...
Barr, John (Creatorcre)
core