Results 101 to 110 of about 995,312 (298)

Recombinant LH in ovarian stimulation

Reproductive BioMedicine Online, 2005
The advent of recombinant gonadotrophins brought significant changes in fertility therapy. Treatment options with recombinant gonadotrophins add more to knowledge on folliculogenesis and ovarian steroidogenesis. Over a decade, recombinant LH (rLH) has been used for clinical trials, and the amount of peripheral LH that is necessary for optimal ...
Gamze Sinem, Caglar, Byron, Asimakopoulos, Nikos, Nikolettos, Klaus, Diedrich, Safaa, Al-Hasani   +4 more
openaire   +2 more sources

Microglial Deubiquitinase OTUD7B Stabilizes STAT3 to Promote Neuroinflammation and Cognitive Decline in Alzheimer's Disease

Advanced Science, EarlyView.
. ABSTRACT Neuroinflammation driven by microglial activation is a defining feature of Alzheimer's disease (AD), yet the molecular mechanisms sustaining this proinflammatory state remain unclear. Here, we identify the deubiquitinase OTUD7B as a critical regulator of microglial activation and AD pathology.
Luyao Li, Hao Tang, Qin Yu, Yuyang Zhang, Binglu Shi, Ying Kong, Leiyu Xu, Jingjing Shao, Chenghong Hu, Lingyu She, Zhe Wang, Haiyi Chen, Aleksandr V. Samorodov, Gang Cao, Xia Zhao, Yi Wang   +15 more
wiley   +1 more source

A case report on ovarian torsion after ovarian stimulation [PDF]

Ovarian torsion is a rare but serious cause of acute abdominal and pelvic pain in women, accounting for 2.7% of gynecologic emergencies. The incidence of ovarian torsion has been reported to be increased due to ovarian hyper stimulation.
Lakshmana, Veena
core   +1 more source

Milder is better? advantages and disadvantages of "mild" ovarian stimulation for human in vitro fertilization

Reproductive Biology and Endocrinology, 2011
In the last decades, several steps have been made aiming at rendering human IVF more successful on one side, more tolerable on the other side. The "mild" ovarian stimulation approach, in which a lower-than-average dose of exogenous gonadotropins is given
Delle Piane Luisa, Salvagno Francesca, Casano Simona, Revelli Alberto   +3 more
doaj   +1 more source

The Natural Product Corramycin Acts as a DNA Gyrase Poison and Overcomes Fluoroquinolone Resistance in Mycobacterium tuberculosis

Advanced Science, EarlyView.
Corramycin, a myxobacterial natural product antibiotic, exhibits potent bactericidal activity against multidrug‐resistant Mycobacterium tuberculosis. The compound hijacks bacterial transporters such as BacA and OppABCD to enter the cell and inhibits DNA synthesis through a previously unrecognized mode of DNA gyrase poisoning, locking the enzyme in an ...
Franziska Fries, Jennifer Herrmann, Michael Dal Molin, Yaëlle Wormser, Timo Risch, Yunsheng Gao, Gareth Prosser, Francesca Gubellini, Ariel Mechaly, Joshua B. Wallach, Anthony Castro, Arka Banerjee, Sari Rasheed, Alexander Horn, Mathias Müsken, Michael Kurz, Lindsay Sonnenkalb, Viola Dreyer, Stefan Niemann, Sönke Andres, Dirk Schnappinger, Uli Kazmaier, Norbert Reiling, Rolf Müller, Jan Rybniker, Stéphanie Petrella   +25 more
wiley   +1 more source

Follicular hyperstimulation dysgenesis: a new explanation for adverse effects of excessive FSH doses during ovarian stimulation

, 2022
Results from analysis of RNA sequencing data produced for oocytes, granulosa cells and cumulus cells from different classes of ovarian follicles obtained with two different doses of FSH during ovarian stimulation in low ovarian reserve heifer dairy ...
James J. Ireland (579072), Kaitlin Karl (12113334), Zaramasina Clark (8937788), Peter Schall (6556788), Keith Latham (6556778), Meghan Ruebel (6556783)   +5 more
core   +1 more source

Ferroptosis Suppression by the M6A Reader IGF2BP1 Underlies Gemcitabine Resistance in Pancreatic Ductal Adenocarcinoma

Advanced Science, EarlyView.
IGF2BP1 promotes gemcitabine resistance in pancreatic cancer by stabilizing m6A‐modified FTH1 transcripts and protecting them in stress granules, thereby suppressing ferroptosis. Pharmacological inhibition of IGF2BP1 disrupts this protective pathway, restores ferroptotic sensitivity, and enhances gemcitabine efficacy in resistant tumors.
Ying‐Qin Zhu, Yue Huang, Jing‐Yuan Ye, Si‐Yuan Lu, Zhi‐De Liu, Ming‐Jian Ma, De‐Liang Fang, Zi‐Yi Zhao, Jin‐Zhao Xie, Jiao Chen, Xiao‐Yu Yin   +10 more
wiley   +1 more source

VlPAG/DRN Microglia Drive Neuropathic Pain‐Induced Depression via a Defined Neuroimmune Axis

Advanced Science, EarlyView.
Peripheral nerve injury (SNI) induces neuropathic pain, activates midbrain microglia, and triggers an NLRP3–IL‐1β–dependent inflammatory cascade. IL‐1β signals through IL‐1R1 on vlPAG/DRN VGLUT2+ neurons (vlPAG/DRNGlu), inducing hyperexcitability and driving the vlPAG/DRNGlu→BNSTGABA circuit to produce the affective component of neuropathic pain ...
Jing Yang, Bing‐Jie Tang, Jia‐Yi Li, Shu‐Lan Xie, Shumin Duan, Junping Chen, Shengmei Zhu, Zhen‐Zhong Xu   +7 more
wiley   +1 more source

Elevated progesterone during ovarian stimulation for IVF

, 2012
There is an ongoing debate regarding the impact of premature progesterone rise on the IVF outcome. The objective of this review is to assess evidence of poorer ongoing pregnancy rate in IVF cycles with elevated serum progesterone at the end of follicular
Al-Azemi, M, Kyrou, D, Devroey, P, Humaidan, P, Fatemi, H M, Kolibianakis, E M, Van Vaerenbergh, I   +6 more
core   +1 more source

External validation of anti-Müllerian hormone based prediction of live birth in assisted conception [PDF]

, 2013
<p>Background - Chronological age and oocyte yield are independent determinants of live birth in assisted conception. Anti-Müllerian hormone (AMH) is strongly associated with oocyte yield after controlled ovarian stimulation.
Alex McConnachie, Amani Khader, Antonio La Marca, Valentina Grisendi, Grisendi, Valentina, Nelson, Scott M., Lloyd, Suzanne M, Fleming, Richard, Khader, Amani, LA MARCA , Antonio, Suzanne M Lloyd, Mcconnachie, Alex, Richard Fleming, Scott M Nelson, Khader, A., La Marca Antonio, La Marca, A., Nelson Scott M, Nelson, S.M., Grisendi, V., Lloyd Suzanne M, McConnachie Alex, Lloyd, S.M., McConnachie, A., Fleming, R., Grisendi Valentina, Fleming Richard, Khader Amani   +27 more
core   +1 more source