Results 71 to 80 of about 3,722,377 (405)

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Malignant Brenner tumor with extensive clear cell features: A valuable diagnostic lesson learned from molecular tumor profiling and AI-based tumor differential tool

Gynecologic Oncology Reports
Background: Malignant Brenner tumor (MBT) with extensive clear cell features mimicking an ovarian clear cell carcinoma (CCC) is exceedingly rare. This case report discusses the diagnostic challenges associated with this unusual histologic finding and ...
John A Steinharter, Corinne Jansen, Hassan Ghani, Apsra Nasir, Marzia Capelletti, Ashley Stuckey, M.Ruhul Quddus, Yun-An Tseng   +7 more
doaj   +1 more source

Comprehensive analysis of serum tumor markers and BRCA1/2 germline mutations in Chinese ovarian cancer patients

Molecular Genetics & Genomic Medicine, 2019
Background The serum tumor markers has been widely used in ovarian cancer diagnosis. BRCA1/2 germline mutations are the most common predisposing factors for ovarian cancer development.
Hongyu Deng, Ming Chen, Xinwu Guo, Jianfu Heng, Xunxun Xu, Limin Peng, Hui Jiang, Guoli Li, Julia X. Day, Jinliang Li, Dongyong Shan, Yinghua Li, Yanjie Zhou, Bin Liu, Lizhong Dai, Xiaochun Wang, Jun Wang   +16 more
doaj   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Study the Expression of Dickkopf-related Protein 3 Immunoreactivity in Serous Epithelial Ovarian Tumors

Medical Journal of Babylon
Background: Dickkopf-related protein 3 (DKK3) is regarded as a tumor suppressor in cancer tissue. DKK3 gene effect has an important role in the prognosis of ovarian cancer with the possibility to discover new line treatment in ovarian cancer.
Ammar Eesa Mahdi, Ali Zaki Naji
doaj   +1 more source

Ovarian microcystic stromal tumor: Radiologic-pathologic correlation

Gynecologic Oncology Reports, 2018
Ovarian microcystic stromal tumor (MST) is characterized by microcysts, solid cellular regions with lobulated growth, and collagenous or fibrous stroma forming hyaline plaques.
Daniel Jeong, Ardeshir Hakam, Mohammad Abuel-Haija, Hye Sook Chon   +3 more
doaj   +1 more source

Small extracellular vesicles containing arginase-1 suppress T-cell responses and promote tumor growth in ovarian carcinoma

Nature Communications, 2019
Tumor-driven immune suppression is a major barrier to successful immunotherapy in ovarian carcinomas (OvCa). Among various mechanisms responsible for immune suppression, arginase-1 (ARG1)-carrying small extracellular vesicles (EVs) emerge as important ...
Małgorzata Czystowska-Kuźmicz, A. Sosnowska, D. Nowis, Kavita Ramji, M. Szajnik, Justyna Chlebowska-Tuz, E. Wolińska, P. Gaj, Magdalena Grazul, Z. Pilch, A. Zerrouqi, Agnieszka Graczyk-Jarzynka, Karolina Soroczynska, S. Cierniak, R. Koktysz, E. Elishaev, Sławomir Gruca, Artur Stefanowicz, R. Błaszczyk, Bartłomiej Borek, Anna Gzik, T. Whiteside, J. Gołąb   +22 more
semanticscholar   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Immuno-reactivity of Engrailed (EN)-2 in Epithelial Ovarian Neoplasms [PDF]

Research in Oncology
Background: Ovarian neoplasm refers to any tumor that originates primarily in the ovary. Epithelial ovarian neoplasms are the most common type of ovarian tumor and are classified based on their histogenetic and immunophenotypic features.
Noha Hassab El-Naby, Amr Abdelkareem, Hatem Awaga, Alshimaa Abdelall, Maisa Mohammed   +4 more
doaj   +1 more source

PARP inhibition: a promising therapeutic target in ovarian cancer [PDF]

, 2015
Ovarian cancer is burdened by the highest mortality rate among gynecological cancers. Gold standard is represented by the association of platinum-taxane -based chemotherapy and radical surgery.
Abdul Halim, T, BENEDETTI PANICI, PIERLUIGI, CASORELLI, ASSUNTA, DI DONATO, VIOLANTE, DOMENICI, LAVINIA, GASPARRI, MARIALUISA, IMPERIALE, LUDOVICA, MARCHETTI, CLAUDIA, MONTI, Marco, MUSELLA, ANGELA, MUZII, LUDOVICO, PALAIA, INNOCENZA, PECORINI, Francesco, RUSCITO, ILARY, SALERNO, LAURA   +14 more
core   +1 more source