Results 51 to 60 of about 10,759 (216)

Ovarian cancer stem cells and targeted therapy

Journal of Ovarian Research, 2019
Background Ovarian cancer has the highest ratio of mortality among gynecologic malignancies. Chemotherapy is one of the most common treatment options for ovarian cancer.
Vahideh Keyvani, Moein Farshchian, Seyed-Alireza Esmaeili, Hadi Yari, Meysam Moghbeli, Seyed-Reza Kazemi Nezhad, Mohammad Reza Abbaszadegan   +6 more
doaj   +1 more source

Ovarian microcystic stromal tumor: Radiologic-pathologic correlation

Gynecologic Oncology Reports, 2018
Ovarian microcystic stromal tumor (MST) is characterized by microcysts, solid cellular regions with lobulated growth, and collagenous or fibrous stroma forming hyaline plaques.
Daniel Jeong, Ardeshir Hakam, Mohammad Abuel-Haija, Hye Sook Chon   +3 more
doaj   +1 more source

Deciphering tumor immune microenvironment differences between high-grade serous and endometrioid ovarian cancer to investigate their potential in indicating immunotherapy response

Journal of Ovarian Research, 2023
Background Ovarian cancer is a significant public health concern with a poor prognosis for epithelial ovarian cancer. To explore the potential of immunotherapy in treating epithelial ovarian cancer, we investigated the immune microenvironments of 52 ...
Hua Yang, Xiangyu Gu, Rong Fan, Qun Zhu, Sen Zhong, Xirun Wan, Qian Chen, Lan Zhu, Fengzhi Feng   +8 more
doaj   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Exploring the impact of microbial dysbiosis on ovarian cancer and the therapeutic potential of probiotics

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Ovarian cancer has a grim prognosis due to its delayed detection and limited therapeutic options. Emerging evidence suggests that the microbiome–metabolome axis may contribute to tumor progression, yet its role in ovarian cancer remains unclear.
Chanyuan Li, Nalan Tu, Xin Ning, Yunyan Cong, Fei Wu, Xiuli Zhang, Runrong Li, Yue Xu, Binqiao Wang, Liqin Jin, Yuanming Shen, Jihong Liu   +11 more
doaj   +1 more source

Problem diagnostic of Krukenberg tumor

Majalah Obstetri dan Ginekologi, 2019
Objectives: to report the case of Krukenberg tumor in 57 years old woman, with complaints of abdominal enlargement since the last 10 months. Case Report: a 57 years old woman, multipara, post menopause, came to our hospital with complaints of enlarging ...
Reza Wangsanagara, Pungky Mulawardhana, Vicky Sumarki, Anny Setijo Rahaju, Tri Wulanhandarini   +4 more
doaj   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Partial autoamputation of an ovary following adnexal torsion with preserved ovarian function in a reproductive-age woman: a case report and literature review

BMC Women's Health
Background Ovarian autoamputation is a rare consequence of adnexal torsion. Preoperative diagnosis is challenging, and ovarian and tubal function on the affected side is rarely preserved once autoamputation has occurred.
Kino Hayashi, Hideaki Tsuyoshi, Akari Nakamori, Michio Watanabe, Yasuo Hayashi, Yuka Hattori, Makoto Orisaka, Yoshio Yoshida   +7 more
doaj   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source