Results 41 to 50 of about 236,085 (267)
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Expression and clinical significance of PTK7 in ovarian serous tumors
Zhongguo aizheng zazhi, 2014 Background and purpose: The protein tyrosine kinase-7 (PTK7) gene may be related to the occurrence and progression of many tumors. This study was aimed to explore the expression of PTK7 in ovarian serous tumors and its relationship with clinical stage ...
王海燕 +9 more
doaj
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
EPİTELYAL OVER TÜMÖRLERİ İLE bcl-2, nm 23 ve c-erbB-2 EKSPRESYONLARI ARASINDAKİ İLİŞKİ
Cerrahpaşa Medical Journal, 2019 Background and Design.- Ovarian cancer is the most common cause of death among all gynecologic malignancies. Genetic alterations important in ovarian tumorigenesis have been identified recently.
Sermin ÖZKAL +5 more
doaj
Endometriosis and ovarian cancer: Their association and relationship
European Journal of Obstetrics & Gynecology and Reproductive Biology: X, 2019 Objectives: To study endometriosis-associated borderline or malignant ovarian epithelial tumors by analyzing their differential clinical features, as well as the histological pattern, survival and immunohistochemical data compared with those without ...
Ernesto Bas-Esteve +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology
Molecular Oncology, EarlyView.This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic +15 more
wiley +1 more source
Management of Borderline Ovarian Tumors
Thai Journal of Obstetrics and Gynaecology, 2018 Borderline ovarian tumors are similar to the other adnexal masses in terms of clinical presentation. Surgery is the main treatment. Because of the young age of the patients and early stage of diseases at the time of diagnosis, fertility-sparing
Chuenkamon Charakorn
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Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
Human Pathology ReportsBackground: Ovarian tumors in women under 20 years of age present unique diagnostic and therapeutic challenges, owing to their diverse histological subtypes.
Saadat Eslami +2 more
doaj +1 more source