Results 51 to 60 of about 45,008 (286)

Living at genetic risk: The patient experience of Lynch syndrome

International Journal of Cancer, EarlyView.
Abstract Lynch syndrome is a germline cancer predisposition syndrome caused by a variant in one of four genes. Lynch syndrome places individuals at significantly higher risk for a range of cancers, especially colorectal and endometrial. Depending on which gene is affected, the risk of ovarian, gastric, small bowel, pancreatic, biliary urothelial, brain,
Nicola Reents, Georgina Hoffmann, Kelly Kohut   +2 more
wiley   +1 more source

Estrogen Treatment After Ovariectomy Protects Against Fatty Liver and May Improve Pathway-Selective Insulin Resistance

Diabetes, 2013
Pathway-selective insulin resistance where insulin fails to suppress hepatic glucose production but promotes liver fat storage may underlie glucose and lipid abnormalities after menopause.
Lin Zhu, W. C. Brown, Qing Cai, A. Krust, P. Chambon, O. McGuinness, John M. Stafford   +6 more
semanticscholar   +1 more source

HIF2A as a prognostic and clinical therapeutic target in ovarian clear cell carcinoma

International Journal of Cancer, EarlyView.
What's New? Ovarian clear cell carcinoma is highly associated with hypoxia. Hypoxia‐inducible factor 2A (HIF2A) is a key regulator of hypoxic responses, but its role in ovarian clear cell carcinoma remains unclear. This study demonstrated the unfavorable prognostic significance of HIF2A expression in ovarian clear cell carcinoma.
Mengxin Jiang, Ken Yamaguchi, Kohei Hamada, Yuko Hosoe, Yuka Mise, Sachiko Kitamura, Zhihong Liu, Hairong Wei, Zhenhai Gao, Mana Taki, Koji Yamanoi, Ryusuke Murakami, Rin Mizuno, Taito Miyamoto, Junzo Hamanishi, Masaki Mandai   +15 more
wiley   +1 more source

Effect of ovarian dysfunction induced ovariectomy and Porphyromonas gingivalis induction to risk of metabolic syndrome: in vivo study

Brazilian Dental Science
Periodontal diseases and metabolic syndrome are related to complicated multifactorial conditions. However, the relationship is not yet evident.
Agustin Wulan Suci-Dharmayanti, Zahara Meilawaty, Tantin Ermawati, Agus Murdojohadi Putradjaka, Zahreni Hamzah   +4 more
doaj   +1 more source

A multilevel perspective on MSH6‐associated Lynch syndrome: Integrating molecular, biological, and clinical insights

International Journal of Cancer, EarlyView.
Abstract Lynch syndrome (LS) is the most common hereditary colorectal cancer syndrome, caused by a germline pathogenic variant in one of the mismatch repair (MMR) genes. Among these, MSH6‐associated LS represents a distinct subtype with unique molecular and clinical characteristics.
Salwa Ben Yahia, Anne‐Sophie van der Werf‐'t Lam, Madalina Cabuta, Maartje Nielsen, Noah C. Helderman   +4 more
wiley   +1 more source

Dietary Collagen Hydrolysates Retard Estrogen Deficiency-Induced Bone Loss through Blocking Osteoclastic Activation and Enhancing Osteoblastic Matrix Mineralization

Biomedicines, 2022
Osteoporosis manifest in postmenopausal women is an osteolytic disease characterized by bone loss, leading to increased susceptibility to bone fractures and frailty.
Soo-Il Kim, Sin-Hye Park, Woojin Na, Yong Chul Shin, Moon-Sik Oh, Young Eun Sim, Yulong Zheng, Ae Hyang Kim, Il-Jun Kang, Young-Hee Kang   +9 more
doaj   +1 more source

Ovariectomy Results in Variable Changes in Nociception, Mood and Depression in Adult Female Rats

PLoS ONE, 2014
Decline in the ovarian hormones with menopause may influence somatosensory, cognitive, and affective processing. The present study investigated whether hormonal depletion alters the nociceptive, depressive-like and learning behaviors in experimental rats
Li-Hong Li, Zhe-Chen Wang, Jin Yu, Yu-Qiu Zhang   +3 more
semanticscholar   +1 more source

Anti‐NMDA receptor autoimmune encephalitis associated with ovarian teratoma: A case series and literature review

International Journal of Gynecology &Obstetrics, Volume 169, Issue 1, Page 23-30, April 2025.
Abstract Autoimmune encephalitis is a group of disorders characterized by symptoms of dysfunction of the limbic and extra‐limbic systems that occur in association with antibodies against intracellular antigens, synapses, or proteins located on the surface of nerve cells. Anti‐NMDA (N‐methyl‐D‐aspartate) receptor encephalitis was first described in 2007
Pham Ba Nha, Nguyen Phuong Tu, Nguyen Viet Ha, Duong Thi Thu Hien, Nguyen Thi Thu Phuong, Nguyen Anh Son, Nguyen Tien Hoang   +6 more
wiley   +1 more source

Effects of 17β-Estradiol and the Japanese Herbal Medicine Keishibukuryogan on the Release and Synthesis of Calcitonin Gene-Related Peptide in Ovariectomized Rats

Journal of Pharmacological Sciences, 2003
: The purpose of this study is to clarify the effects of 17β-estradiol and the Japanese herbal medicine Keishi-bukuryo-gan on the release and synthesis of calcitonin gene-related peptide (CGRP) in ovariectomized (OVX) rats.
Masamichi Noguchi, Yasushi Ikarashi, Mitsutoshi Yuzurihara, Yoshio Kase, Shuichi Takeda, Masaki Aburada   +5 more
doaj   +1 more source

Robot‐assisted resection of diaphragmatic and hepatorenal recess peritoneal endometriosis: Two cases and a narrative review

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract In this report, we describe two cases of diaphragmatic endometriosis with concurrent hepatorenal recess peritoneal involvement managed using robotic‐assisted laparoscopic surgery with the da Vinci Xi platform. In both patients, diaphragmatic implants and hepatorenal recess peritoneal lesions were excised en bloc, followed by resection of ...
Xiaoming Guan, Qiannan Yang, Daniel Y. Lovell, Chunhua Zhang   +3 more
wiley   +1 more source