Results 91 to 100 of about 162,204 (317)

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

That Takes Ovaries! [PDF]

, 2006
Adapted from the book THAT TAKES OVARIES! BOLD FEMALES AND THEIR BRAZEN ACTS a collection of real-life experiences and first-person narratives edited by Rivka Solomon Director: Randi Jennifer Collins Hard Assistant Director: Emily Collins Hard Scenic ...
Parkland College
core   +1 more source

Follicular development in ovaries of zebu fetuses (Bos taurus indicus) [PDF]

Biotemas, 2009
In this study we utilized 36 samples from the ovaries of female fetuses (with three to eight months’ gestation) of the Nelore breed of zebus (Bos taurus indicus) in six separate groups with six samples each. For the histological and morphometric analysis,
Guilherme de Paula Nogueira, Roberto Gameiro de Carvalho, Silvia Helena Venturoli Perri, Michael Babosa Biagi, Cristina Maria Rodrigues Monteiro   +4 more
doaj  

Therapeutic Role of Annona muricata Fruit and Bee Venom Against MNU-Induced Breast Cancer in Pregnant Rats and its Complications on the Ovaries

Breast Cancer: Targets and Therapy, 2021
Abd El-Fattah BM El-Beltagy,1 Hassan IH Elsyyad,2 Karoline K Abdelaziz,1 Amira S Madany,1 Mohamed M Elghazaly1 1Zoology Department, Faculty of Science, Damanhour University, Damanhour, Egypt; 2Zoology Department, Faculty of Science, Mansoura University ...
El-Beltagy AEFBM, Elsyyad HIH, Abdelaziz KK, Madany AS, Elghazaly MM   +4 more
doaj  

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

The effect of high temperature on swine ovarian function in vitro

Veterinární Medicína, 2010
The aim of the present study was to understand the hormonal mechanisms behind the effect of high temperatures on reproductive function. It was proposed that high temperatures can directly alter production of ovarian hormones and/or the response of ...
A.V. Sirotkin, M. Kacaniova
doaj   +1 more source

TERATOMA OF OVARY [PDF]

Southern Medical Journal, 1908
n ...
openaire   +2 more sources

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Expression of genes encoding steroidogenic CYP in steroidogenic ovaries and MRTs compared to non steroidogenic ovaries. [PDF]

, 2013
Expression ratios and p values (italic) for the genes encoding CYPs previously characterized as steroidogenic CYPs, in ovaries of blood-fed females at 5 h, 16 h, 22 h post blood-meal (PBM) and in male reproductive tracts (MRTs) compared to ovaries from ...
Emilie Guittard (492685), Jean-Philippe David (181853), Jean-Claude Jacques (246234), Hilary Ranson (23879), Emilie Pondeville (492684), Chantal Dauphin-Villemant (492686), Catherine Bourgouin (106861), Annick Maria (454209)   +7 more
core   +1 more source

Exceptional longevity of mammalian ovarian and oocyte macromolecules throughout the reproductive lifespan

eLife
The mechanisms contributing to age-related deterioration of the female reproductive system are complex, however aberrant protein homeostasis is a major contributor.
Ewa K Bomba-Warczak, Karen M Velez, Luhan T Zhou, Christelle Guillermier, Seby Edassery, Matthew L Steinhauser, Jeffrey N Savas, Francesca E Duncan   +7 more
doaj   +1 more source