Results 181 to 190 of about 325,405 (336)

USP9X as a Candidate Mediator of Prenatal Aspirin‐Induced Ovarian Reserve Reduction in Offspring Mice

Advanced Science, EarlyView.
This study suggests that prenatal aspirin exposure is associated with reduced ovarian reserve in offspring, associated with HDAC1‐linked epigenetic downregulation of Usp9x as a candidate mechanism. These preclinical findings provide new insights into fetal‐origin ovarian disorders and contribute to the evidence base concerning aspirin's gestational ...
Yating Li, Caiyun Ge, Wai Yen Yim, Hui Feng, Tiancheng Wu, Lu Chen, Qiaohua Xiong, Shumin Pan, Mei Wang, Huijun Chen, Yuanzhen Zhang, Hui Wang   +11 more
wiley   +1 more source

Cyst-independent oocyte phagocytosis builds the female reproductive reserve in mice. [PDF]

EMBO Rep
Zhang Y, Bo Y, Cheng K, Wang G, Mu L, Liang J, Li L, Geng K, Yang X, Hu X, Wang W, Jia L, Xu X, Hu J, Wang C, Wang F, Ke Y, Xia G, Zhang H.   +18 more
europepmc   +1 more source

Irritable bowel syndrome, endometriosis and polycystic ovary syndrome: is there a link?

, 2019
Ashwath Narayan Ramji
openalex   +2 more sources

Anti‐PD‐1 Nanobody‐Armored MSLN CAR‐T Therapy for Malignant Mesothelioma: Preclinical and Clinical Studies

Advanced Science, EarlyView.
A novel therapy using engineered immune cells (NAC‐T cells) showed promise for refractory malignant mesothelioma. Based on the encouraging preclinical data, the first‐in‐human trial is initiated, demonstrating tolerable safety and promising anti‐tumor activity (ORR 63.6%, DCR 100%, including one CR).
Yan Sun, Haochen Yang, Qing Xu, Xingya Li, Jinxing Lou, Jianchun Duan, Jiachen Xu, Zhuqing Liu, Yong Xia, Zhicai Lin, Linlin Li, Dan Sun, Jiaguo Li, Tao Liu, Jun Guo, Wenfeng Xu, Weimin Zhu, Yi Liu, Boyang Sun, Jia Zhong, Lijie Rong, Qijun Qian, Chenqi Xu, Jie Wang   +23 more
wiley   +1 more source

MON-207 Identification of Monogenic Causes of Polycystic Ovary Syndrome by High Throughput Sequencing

, 2019
Raiane P Crespo, Thaís da Rocha, Gustavo Arantes Rosa Maciel, Sylvia Asaka Yamashita Hayashida, Edmund Chada Baracat, Antônio Marcondes Lerário, Mirian Yumie Nishi, Ana Cláudia Latronico, Berenice B. Mendonça, Larissa Garcia Gomes   +9 more
openalex   +1 more source

Discovery of a Novel and Potent Kir4.1 Inhibitor as a Safe and Rapid‐Onset Antidepressant Agent in Mice

Advanced Science, EarlyView.
The preferred derivative JX3212 demonstrates strong inhibitory activity against Kir4.1 with favorable druggability and shows significant antidepressant efficacy in vivo. Abstract Major depressive disorder is a serious psychiatric disorder for which novel and fast‐acting antidepressants are required.
Sisi Wang, Xiaoyu Zhou, Mengdan Li, Chao Zhang, Haiyan Xu, Jingyi He, Li Zhan, Yueling Gu, Hao Gu, Tianyu Tu, Hanfang Liu, Taotao Lu, Yueming Zheng, Jian Li, Zhaobing Gao, Yixiang Xu   +15 more
wiley   +1 more source

Retinoic Acid and Calcitriol Protect Mouse Primordial Follicles from Cyclophosphamide Treatment-Induced Apoptosis. [PDF]

Antioxidants (Basel)
He S, Zhang X, Zhou W, Chen Y, Liu F, Wang W, Wei H, Du Y, Zhang M.   +8 more
europepmc   +1 more source

Engineered Mesenchymal Stem Cell–NK Cell Complexes for Spatially Targeted and Functionally Revitalized Cancer Immunotherapy

Advanced Science, EarlyView.
IL‐15‐engineered stem cell–NK cell complexes, assembled via bioorthogonal chemistry, enable effective lung cancer immunotherapy. Abstract Natural killer (NK) cells represent a powerful immunotherapeutic strategy due to their intrinsic cytotoxicity and ability to target tumor cells independently of antigen presentation.
Qian Zhang, Bo Yin, Munaiwaier Sabier, Youlan Yang, Mengling Wu, Zhouping Zhao, Xuanzhi Luo, Yuehong Zhong, Xiuming Zhu, Jie Zhang, Jing Wang, Kai Chen, Fei Ruan, Wei Zhang, Zhimin Lu, Jiong Wang   +15 more
wiley   +1 more source

The Combinatory Effect of <i>Salvia officinalis and Nigella sativa</i> Extracts on Polycystic Ovarian Syndrome Induced in Mice. [PDF]

Glob Adv Integr Med Health
Faour H, Hachem S, Al Battal M, Borjac J.   +3 more
europepmc   +1 more source

Somatotype, metabolic features, and psychological distress in women with polycystic ovary syndrome: a case–control study

Vijayakumar K, Rajesh Karekar, Pranavi Sharma   +2 more
openalex   +1 more source