Results 191 to 200 of about 251,258 (312)

Characterizing ovarian histopathology in transgender and gender-diverse patients on testosterone: Informing shared decision-making in gender-affirming care. [PDF]

Front Reprod Health
Thigpen KG, Gontarczyk Uczkowski N, Godecker AL, Seifer M, Sabgir A, Hanks L.   +5 more
europepmc   +1 more source

Inhibition of SIRT7 Overcomes Radioresistance in Pancreatic Neuroendocrine Tumors by Reactivating MEN1 Expression

Advanced Science, EarlyView.
Pancreatic neuroendocrine tumors frequently silence MEN1 through epigenetic mechanisms. Here, SIRT7 recruits DNMT1 to the MEN1 promoter, drives hypermethylation, and enhances DNA repair. Inhibiting SIRT7 restores MEN1, reduces MRN complex abundance, impairs double‐strand break repair, and sensitizes PanNET models to radiation, supporting SIRT7 as a ...
Jianyun Jiang, Yan Wang, Yi Qin, Luohai Chen, Xiaowu Xu, Guixiong Fan, Desheng Jing, Miaoyan Wei, Xianjun Yu, Junfeng Xu, Shunrong Ji, Jie Chen   +11 more
wiley   +1 more source

Uev1A counteracts oncogenic <i>Ras</i> stimuli in both polyploid and diploid cells. [PDF]

Elife
Zhang Q, Wang Y, Fu X, Wang Z, Zhang Y, Yan L, Wang Y, Yang M, Song D, Zhang R, Zhang H, Wu S, Zhao S.   +12 more
europepmc   +1 more source

N4‐acetylcytidine in LncRNA Gm26917 Promotes Translation in Female Germline Stem Cells by Recruiting Ribosomal Protein mRNA via EEF1A1

Advanced Science, EarlyView.
This work establishes that ac4C modification on lncRNA Gm26917 governs its spatial interactions with Rpl10 mRNA, and RBP EEF1A1 mediates the interaction between Gm26917 and Rpl10. It elucidates a novel ac4C‐Gm26917‐EEF1A1‐Rpl10 axis in FGSC maintenance both in vitro and in vivo, and provides a potential molecular target for modulating germ cell ...
Xinyue Li, Xiaopeng Hu, Ji Wu
wiley   +1 more source

Transcriptome of Coxiella-like endosymbionts in Haemaphysalis longicornis during blood feeding. [PDF]

J Vet Med Sci
Kusakisako K, Abdelbaset AE, Umemiya-Shirafuji R, Yamagishi J, Nonaka N, Ikadai H, Nakao R.   +6 more
europepmc   +1 more source

Endothelial GPR68 Is Essential for Arteriogenesis and Represents a Therapeutic Target in a Model of Peripheral Artery Disease

Advanced Science, EarlyView.
Endothelial GPR68 is identified as a critical regulator of collateral artery growth in peripheral artery disease. Genetic and pharmacological evidence demonstrates that GPR68 integrates hemodynamic cues to drive monocyte recruitment and inflammatory remodeling, thereby promoting collateral arteriogenesis and tissue perfusion after ischemia ...
Yiyan Song, Senyi Peng, Zhilei Huang, Miao Yu, Mingyue Wu, Yuexin Zhu, Zeyi Zhou, Yongshan Liu, Yalin Zhang, Yu Huang, Zhongxing Wang, Fu‐Li Xiang, Jie Xu   +12 more
wiley   +1 more source

Changes in ovarian hardness and elasticity affect the development and function of secondary follicles. [PDF]

Sci Rep
Kawai T, Shimada M.
europepmc   +1 more source

Quantitative Mass Spectrometry‐Based Biodistribution of Monoclonal Antibodies: An Alternative to Radio‐Biodistribution

Advanced Science, EarlyView.
Monoclonal antibodies are powerful anticancer therapeutics targeting tumor‐associated antigens. Mass spectrometry enables precise and accurate quantification of mAbs in tumor plasma and healthy organs. Unlike ligand binding assay and radioactivity, mass spectrometry does not suffer from matrix effects and labelling artefacts while facilitating method ...
Domenico Ravazza, Sheila Dakhel Plaza, Samuele Cazzamalli, Andrea Ciamarone, Andrea Galbiati, Riccardo Stucchi, Frederik Peissert, Emanuele Puca, Dario Neri, Ettore Gilardoni   +9 more
wiley   +1 more source

RNA exosome component EXOSC10 variants identified in a patient with premature ovarian insufficiency†. [PDF]

Biol Reprod
Kline BL, Moran IL, Cai X, Siddall NA, Wijaya F, Dulon J, Bakhshalizadeh S, Bell KM, Jaillard S, Robevska G, van den Bergen JA, Touraine P, Ayers KL, Hime GR, Sinclair AH, Tucker EJ.   +15 more
europepmc   +1 more source

The Fruits of Conservatism in the Treatment of Ovarian Pathology [PDF]

, 1959
Christian, Howard J.
core   +1 more source