Results 201 to 210 of about 251,258 (312)

GnRH-agonist implants suppress reproductive function and affects ovarian LHR and FSHR expression in prepubertal female cats [PDF]

, 2017
Axner, Bristol-Gould, Brown, Brown, Carranza, Carranza, Chatdarong, Chowdhury, Faya, Goericke-Pesch, Goodrowe, Gudermuth, Ishibashi, Johnston, Kelly, Kinoshita, M. Khalid, Munson, N.S. Mehl, Orosz, Pelican, Pelican, Ponglowhapan, Ponglowhapan, Ponglowhapan, Risso, S. Sirivaidyapong, S. Srisuwatanasagul, Saint-Dizier, Sano, T. Swangchan-Uthai, Tharasanit, Toydemir, Trigg, Wright   +34 more
core   +2 more sources

Phenotypic Diversity and Outcomes in Pediatric NMDA Receptor Encephalitis: A 15‐Year Retrospective Study from the Largest Children's Hospital in the United States

Advanced Science, EarlyView.
ABSTRACT Anti‐NMDAR encephalitis (NMDARE) is an autoantibody‐mediated disorder characterized by seizures, movement disorders, neurocognitive deficits, and psychosis, but the complete phenotypic heterogeneity, and outcomes are incompletely understood in children.
Alexander J. Sandweiss, Timothy Erickson, Yike Jiang, Varun Kannan, Jonathan M. Yarimi, Kristen S. Fisher, Nikita Shukla, Tim Lotze, Eyal Muscal, Kristy O. Murray   +9 more
wiley   +1 more source

Salidroside Ameliorates Polycystic Ovary Syndrome in Mice by Regulating the AKT/NF-κB/NLRP3-HAS2 Axis. [PDF]

Food Sci Nutr
Li JH, Shi SM, Liu LY, He YY, Jia GL, Qu LY, Chi ZC, Leng JH, Xu HJ, Lan T, Yan DL, Kong IK, Yu XF, Zhang MJ, Jin YX.   +14 more
europepmc   +1 more source

Macrophage Extracellular Traps in Immunity and Cancer

Advanced Science, EarlyView.
As a macrophage‐mediated innate defense mechanism, the dysregulated release of METs drives chronic inflammation and influences tumor progression. Furthermore, METs exhibit a functional duality within the tumor microenvironment, capable of both promoting and suppressing tumor development.
Junyao Li, Eugenie Nepovimova, Adam Grundel, Lukas Peter, Qinghua Wu, Kamil Kuca   +5 more
wiley   +1 more source

The Stimulating Effect of Low-Molecular-Weight Luteinizing Hormone Receptor Agonist on Steroidogenesis and Ovulation in Female Rats with Dehydroepiandrosterone-Induced Polycystic Ovary Syndrome. [PDF]

Int J Mol Sci
Derkach KV, Pechalnova AS, Zorina II, Morina IY, Bayunova LV, Romanova IV, Fedorchuk IV, Ryzhov JR, Chernenko EE, Sorokoumov VN, Shpakov AO.   +10 more
europepmc   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

H3K9me2 is a determinant for the mitosis-to-meiosis transition in female germ cells. [PDF]

Cell Death Dis
Hu Y, Zhou H, Shi L, Liu K, Meng X, Guo X, Shan L, Hu F, Liu Y, Zhang T, Zhou Y.   +10 more
europepmc   +1 more source

Leveraging Macrophage Metabolic Reprogramming for Enhanced Anti‐Tumor Immunity

Advanced Science, EarlyView.
Tumor‐associated macrophages (TAMs) are key regulators of the tumor microenvironment (TME), with their metabolic states playing a critical role in tumor progression or regression. This review summarizes current understanding of TAM metabolic plasticity alongside cutting‐edge bioengineering innovations, outlining a roadmap for transforming the ...
Zhiyun Liu, Lingyao Zeng, Xulin Gan, Yilin Zhou, Han Shen, Dan Wu, Xin Shou, Minmin Jiang, Liyun Shi   +8 more
wiley   +1 more source

Dysregulation of alternative splicing patterns in the ovaries of reproductively aged mice. [PDF]

Reproduction
Alsamaraee AT, Correll VL, Nyalwidhe JO, Brachova P, Alvarez NS, Alvarez NS.   +5 more
europepmc   +1 more source

SpatialESD: Spatial Ensemble Domain Detection in Spatial Transcriptomics

Advanced Science, EarlyView.
ABSTRACT Spatial transcriptomics (ST) measures gene expression while preserving spatial context within tissues. One of the key tasks in ST analysis is spatial domain detection, which remains challenging due to the complex structure of ST data and the varying performance of individual clustering methods. To address this, we propose SpatialESD, a Spatial
Hongyan Cao, Gaiqin Liu, Jingyi Xia, Runle Chen, Tong Wang, Xiaoling Yang, Ruiling Fang, Yanhong Luo, Ping Zeng, Hongmei Yu, Yanbo Zhang, Yuehua Cui   +11 more
wiley   +1 more source