Results 211 to 220 of about 325,405 (336)

Inhibition of SLC11A1‐Mediated Lysosomal Iron Accumulation in Microglia Promotes Repair Following White Matter Stroke

Advanced Science, EarlyView.
Genetic and pharmacological inhibition of SLC11A1 functioning as an H+/Fe2+ antiporter–mediated lysosomal iron accumulation in microglia promotes lysosomal lumen acidification, increases CTSD expression, enhances lysosomal myelin debris uptake and degradation, and promotes repair following white matter stroke. ABSTRACT White matter stroke (WMS) results
Lingling Qiu, Yajie Zhang, Yushi Tang, Hongli Hu, Ying Zhang, Junwen Xue, Hao Wang, Yecheng Wang, Chunfeng Liu, Jia Jia, Jian Cheng, Yongjun Cao   +11 more
wiley   +1 more source

Potential FSH-mediated molecular pathway to regulate follicle development in striped hamsters (Cricetulus barabensis) supported by strong correlative evidence. [PDF]

PLoS One
Xue H, Zheng Y, Fan C, Xu J, Chen L, Wu M, Xu L.   +6 more
europepmc   +1 more source

Transgenic Tomato Strategies Targeting Whitefly Eggs from Apoplastic or Ovary-Directed Proteins [PDF]

Natalie S. Thompson, Aliya Fathima Anwar, David Krum, Michael Ream, Eva Mei Shouse, Zachary Weston, Yun-Ru Chen, Aisa Sam, Michihito Deguchi, Samwel Muiruri, Sairam Rudrabhatla, Wayne R. Curtis   +11 more
openalex   +1 more source

Targeting WEE1 in ARID1A/TP53 Concurrent Mutant Colorectal Cancer by Exploiting R‐Loop Accumulation and DNA Repair Deficiencies

Advanced Science, EarlyView.
ARID1A, a SWI/SNF complex component, is frequently mutated in colorectal cancer (CRC). CRC with ARID1A/TP53 concurrent mutations shows marked sensitivity to WEE1 inhibition. ARID1A loss induces R‐loop‐mediated replication stress, impairs ATF3 transcription, and amplifies WEE1i‐induced DNA damage, suggesting a promising therapeutic vulnerability ...
Chi Zhang, Yanjing Zhu, Luoyan Ai, Jingyuan Wang, Shan Yu, Yichen Wang, Xiaojing Xu, Mengling Liu, Yiyi Yu, Mengxuan Zhu, Yutong Liu, Zhenghang Xu, Haojie Zhou, Huishan Li, Qihong Huang, Qing Liu, Ke Peng, Tianshu Liu   +17 more
wiley   +1 more source

In vitro system completely restores oogenesis in congenitally infertile mice. [PDF]

Hum Reprod
Yoshida K, Kimura S, Taguchi M, Morimoto H, Kanatsu-Shinohara M, Shinohara T, Obata Y.   +6 more
europepmc   +1 more source

Remote Modulation of Single‐Atom Catalyst Boosts High‐Valent Cobalt–Oxo Species Generation for Water Purification and Detoxification

Advanced Science, EarlyView.
This study develops a phosphorus‐doped cobalt single‐atom catalyst that enhances high‐valent cobalt–oxo species generation for water purification. This atomic‐level tuning boosts the catalyst's activity by 3.5 times, enabling efficient pollutant degradation. A continuous‐flow reactor achieves high, long‐term removal efficiency, producing water with low
Wen‐Min Wang, Zheng‐Wei Yang, De‐Xiu Wu, Wen‐Long Wang, Qian‐Yuan Wu   +4 more
wiley   +1 more source

Plant Virus-Induced Inheritable Apoptosis Drives Reproductive Costs in Female Insect Vectors to Balance Viral Biparental Transmission. [PDF]

Adv Sci (Weinh)
Wu H, Wan W, Liang Q, Yang H, Lu C, Wei T, Chen Q.   +6 more
europepmc   +1 more source

Bushenhuoluo Decoction improves polycystic ovary syndrome by regulating exosomal miR-30a-5p/ SOCS3/mTOR/NLRP3 signaling-mediated autophagy and pyroptosis [PDF]

Qun Huang, Yuanbin Li, Zhuang Chen, Huiping Ou, Yanjiao Tan, Hui Lin   +5 more
openalex   +1 more source

NAD+‐Dependent Enzyme SIRT3 Limits Intestinal Epithelial Cell Functions Through NAD+ Synthesis Pathway in Colorectal Cancer

Advanced Science, EarlyView.
Microbiota‐derived quinolinic acid is used as an alternative source of replenishing the intracellular NAD+ pool induced by SIRT3 deficiency to regulate intestinal epithelial cell and T cell function, which has implications for targeting intestinal epithelial cells as an approach to the treatment of immune‐associated diseases, including colorectal ...
Ruiying Niu, Yingjie Dong, Jianghui Tong, Jingxuan Xia, Longhao Zhao, Zi Geng, Yingxin Lin, Jinghe Zhang, Xinyi Liu, Manqi Fang, Xi Jin, Yujing Bi, Guangwei Liu   +12 more
wiley   +1 more source

Maternal sleep deprivation during pregnancy induced offspring germ cells loss through ferroptosis. [PDF]

Cell Death Discov
Liu Q, Yan J, Wang H, Wang T, Zhang K, Li A, Wang J, Zhang T, Shen W, Li L.   +9 more
europepmc   +1 more source