Results 91 to 100 of about 3,276,165 (313)
MANAGING PEST RESISTANCE: THE POTENTIAL OF CROP ROTATIONS AND SHREDDING [PDF]
The current debate over resistance management plans mandated by the Environmental Protection Agency for transgenic crops ignores management practices that are complementary to refuge schemes.
Babcock, Bruce A., Secchi, Silvia
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Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
A New GPS-based Digital Protection System for Smart Grids in Loop Structure
EAI Endorsed Transactions on Energy Web, 2014 This paper presents a new digital protection system to solve the protection challenges in future smart grids, i.e., fast protection and fault isolation in a loop-structured system with limited magnitude of fault current.
X. Liu, M. Steurer, M. Yu
doaj +1 more source
‘The Lighthouse Invites the Storm’ – Professional Regulation of Nursing in England and Wales – Under Threat [PDF]
, 2012 This paper explores current issues related to the professional regulation of nursing in England and Wales and considers whether self-regulation is currently under threat.
Young, Andy
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Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Erosion-corrosion behaviour of Zirconia WC-6Co, WC-6Ni and SS316 [PDF]
, 2015 The current study investigates a ceramic, two cermets and a metal under solid-liquid impingement with 3.5% NaCl and 150mg/l hydraulic fracturing sand at two extreme angles of impact, 90° and 20°.
Andrews, N. +3 more
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Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
Book Review: Archeology in the Eastern Planning Region, Texas: A Planning Document [PDF]
, 1996 With the passage of the National Historic Preservation Act in 1966 and ensuing regulatory guidelines, a mandate for the development of The State Historic Preservation Plan was clearly established. During the late 1960s and the 1970s, because of limited
Brooks, Robert L.
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Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source