Results 51 to 60 of about 92,637,410 (303)

First Sagittarius A* Event Horizon Telescope Results. IV. Variability, Morphology, and Black Hole Mass

, 2023
In this paper we quantify the temporal variability and image morphology of the horizon-scale emission from Sgr A*, as observed by the EHT in 2017 April at a wavelength of 1.3 mm.
The Event Horizon Telescope Collaboration
core   +1 more source

A Cognitive Beamforming Method via Range-Doppler Map Features for Skywave Radar

Remote Sensing, 2022
For skywave over-the-horizon radar, beamforming techniques are often used to suppress airspace radio frequency interference because the high-frequency band is shared by many devices.
Zhenshuo Lei, Hui Chen, Zhaojian Zhang, Gaoqi Dou, Yongliang Wang   +4 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Distributed Multistatic Sky-Wave Over-the-Horizon Radar’s Positioning Algorithm for the Marine Target

International Journal of Antennas and Propagation, 2021
This paper establishes a distributed multistatic sky-wave over-the-horizon radar (DMOTHR) model and proposes a semidefinite relaxation positioning (SDP) algorithm to locate marine ship targets.
Fangyu Ren, Huotao Gao, Lijuan Yang, Sang Zhou   +3 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Multiwavelength View of the M87 Black Hole Captured by the Event Horizon Telescope [PDF]

, 2021
In 2017, the first image of the center of the M87 galaxy was captured by the Event Horizon Telescope (EHT). It revealed a ring morphology and a size consistent with theoretical expectations for the light pattern around a weakly accreting supermassive ...
PRINCIPE G, Event Horizon Telescope (Eht) Multi-Wavelength Science Working Group, M., VERITAS Collaboration, Lucchini, Eht Collaboration, MAGIC Collaboration, Eavn Collaboration, Fermi-Lat Collaboration, H. E. S. S. Collaboration   +9 more
core   +1 more source

The Event Horizon General Relativistic Magnetohydrodynamic Code Comparison Project

Supplementary materials for "The Event Horizon General Relativistic Magnetohydrodynamic Code Comparison Project", ApJS (2019)
Porth, Oliver, The Event Horizon Telescope Collaboration   +1 more
core   +2 more sources

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source