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Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
There is a difficulty in setting the coordination of over-current protection in the distribution network with distributed power sources and widely laying optical fiber for differential protection in the distribution network, the study on engineering ...
CHEN Yongkui, LI Hongmei, ZHU Jihong
doaj +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Protecting AC microgrids (MGs) is a challenging task due to their dual operating modes—grid-connected and islanded—which cause sudden variations in fault currents. Traditional protection methods may no longer ensure network security.
León F. Serna-Montoya +3 more
doaj +1 more source
Simplified method for protecting the power capacitor from over-voltage/over-current
A simplified method for protecting the power capacitor from over-voltage/over-current is proposed. The proposed method retrieves the voltage across the power capacitor to calculate the root mean square (RMS) values of the power capacitor voltage and the power capacitor current.
Hurng-Liahng Jou +4 more
openaire +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Design of a new type of protection circuit of mine-used intrinsic safety power supply
The paper put forward a design scheme of a new type of protection circuit of mine-used intrinsic safety power supply with LM339 comparator and MAX4080SASA current detection chip based on the analysis of advantages and disadvantages of traditional ...
ZHOU Xue-feng
doaj
A Structure-Reconfigurable Soft-Switching DC-DC Converter for Wide-Range Applications
In this paper, a structure-reconfigurable resonant DC-DC (direct current − direct current) converter is presented. By controlling the state of the auxiliary switch, the converter could change the resonant structure to acquire a high efficiency and ...
Xianxu Huo +5 more
doaj +1 more source
The escalating significance of system reliability and resilience is transforming the planning and operation of contemporary distribution systems. To accomplish self-healing against power outages, advanced emerging technologies and devices such as smart ...
Alok Jain, Suman Bhullar
doaj +1 more source

