Results 51 to 60 of about 685,222 (270)

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Research on the intelligent control system for lithium-ion aluminium shell power battery module stacking

Mechanics & Industry
During the stacking and welding process of lithium-ion aluminium shell power battery modules, the accumulation of cell size errors can easily cause the module length to exceed the tolerance range, affecting the module length qualification rate and the ...
Sheng Qingshan, Sirikham Adisorn, Konpang Jessada, Wu Heng   +3 more
doaj   +1 more source

Monitoring the technical condition of autonomous electrical systems with electric drive [PDF]

E3S Web of Conferences, 2019
The article discusses the structure of autonomous electrical systems with an electric drive and an electric energy generation system. An approach is described for assessing the overall efficiency of technological cycle equipment with specification of ...
Korolev Nikolay, Solovev Sergey
doaj   +1 more source

Development and Validation of an Overall Equipment Efficiency Measurement Model for Supporting Operational Excellence

IFAC-PapersOnLine, 2022
This paper reports on an empirical study undertaken to investigate the overall equipment effectiveness (OEE) of several strategically selected production lines in a manufacturing plant. The study involved the development and application of bespoke data acquisition systems to capture shop-floor level data, as well as the validation of a novel OEE model ...
Kiridena, Senevi, Li, Wenxu, Dwight, Richard   +2 more
openaire   +2 more sources

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Implementation of Total Productive Maintenance on Frame Welding Machine Maintenance Using the Overall Equipment Effectiveness (OEE) Method at PT Electronics Components Indonesia

International Journal of Innovative Science and Research Technology
PT. Electronics Components Indonesia manufactures capacitors and focuses on enhancing productivity and operational efficiency of the frame welding machines through effective maintenance.
Yerikho Alexander, Fibi Eko Putra, Putri Anggun Sari   +2 more
semanticscholar   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Incorporating KPIs in the Quantification of Overall Efficiency of Rolling Stock of Railways

Engineering Proceedings
The overall efficiency of the rolling stock of railways can be calculated by taking into account three parameters: availability, performance, and quality.
Qamar Mahboob, Muhammad Aftab Aalam, Sanan Tahir, Zhiwen Wang, Qiyuan Mao, Zidong Tan   +5 more
doaj   +1 more source