Results 61 to 70 of about 1,547,267 (302)

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Efficiency of systems of heat supply with introduction of automated individual heating substations [PDF]

open access: yesE3S Web of Conferences, 2019
Article is devoted to increasing efficiency of heat supply systems. We demonstrate research results and an analysis of dependences of overall heat supply system performance indicators at various levels of equipment of consumers with the automated ...
Zvonareva Yu. N.   +5 more
doaj   +1 more source

Hydraulic Wind Power Transfer Technology [PDF]

open access: yes, 2013
poster abstractExpiration of renewable energy tax credits in general and a gap in wind energy breakthroughs in particular have caused high cost of wind energy and technological dependency on countries such as China and Germany.
Izadian, Afshin
core  

RIPK4 function interferes with melanoma cell adhesion and metastasis

open access: yesMolecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski   +9 more
wiley   +1 more source

A decentralized predictive maintenance system based on data mining concepts [PDF]

open access: yes, 2010
In the last years we have assisted to several and deep changes in industrial manufacturing. Induced by the need of increasing efficiency, bigger flexibility, better quality and lower costs, it became more complex [1].
Bastos, Pedro   +2 more
core  

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

Incorporating KPIs in the Quantification of Overall Efficiency of Rolling Stock of Railways

open access: yesEngineering Proceedings
The overall efficiency of the rolling stock of railways can be calculated by taking into account three parameters: availability, performance, and quality.
Qamar Mahboob   +5 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

open access: yesFEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz   +6 more
wiley   +1 more source

Performance Improvement of Wave Plate Mist Eliminator through Geometry Modification

open access: yesAerosol and Air Quality Research, 2023
In this study, the geometry of a popular wave plate type mist eliminator used in the wet flue gas desulfurization process was improved. Subsequently, the equipment was fabricated and experimentally evaluated.
Jung-Hun Noh   +2 more
doaj   +1 more source

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