Results 71 to 80 of about 685,222 (270)

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Green overall equipment effectiveness (GOEE): Theoretical development and simulation-based analysis for sustainable manufacturing

Cleaner Engineering and Technology
Integrating sustainability considerations into equipment-level performance measurement remains a methodological challenge in manufacturing systems. While MES/SCADA platforms enable high-frequency operational monitoring, conventional Overall Equipment ...
Supatchaya Chotayakul, Varathorn Punyangarm   +1 more
doaj   +1 more source

Intelligent infrared diagnosis method for traction power supply equipment based on Mask-RCNN

机车电传动, 2022
Aiming at the low efficiency of the manual infrared image processing and the low intelligence degree in the state diagnosis of traction power supply equipment, a two-layer network model based on Inception-V3 and Mask-RCNN was proposed in this paper.
LIN Shan, DENG Shu, CHEN Xiaoli, WANG Lin, CHENG Hongbo   +4 more
doaj  

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

FORECASTING OVERALL EQUIPMENT EFFICIENCY IN ELECTRONIC INDUSTRY USING INDUSTRIAL INTERNET OF THINGS AND MACHINE LEARNING METHODS

Измерение, мониторинг, управление, контроль
Background. The article considers modern methods for forecasting the overall efficiency of equipment, allowingto identify productivity reserves and manage production losses at industrial enterprises in the contextof digitalization and the implementation ...
Vitaly R. Aleksandrov, Aleksey A. Shchetkin, Aleksandr S. Bevz, Olga A. Zemskova, Sergey S. Sakhnenko   +4 more
doaj   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Artificial Intelligence and Mental Well‐Being in Adult Education: Implications for Practice and Professional Responsibility

New Directions for Adult and Continuing Education, EarlyView.
ABSTRACT Mental well‐being is central to adult learner success, yet many adult education institutions lack capacity to provide timely and accessible support. This article examines how artificial intelligence (AI) can strengthen mental health–adjacent supports in adult and continuing higher education, with attention to professional practice and ...
Adam L. McClain, Thomas Wade
wiley   +1 more source

Effectiveness of rTMS on Working Memory and Inhibitory Impairments in Patients With Post‐Stroke Executive Deficits

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Considerable efforts have been dedicated to developing effective treatments for post‐stroke executive impairment (PSEI), among which repetitive transcranial magnetic stimulation (rTMS) has shown great potential. This study aimed to investigate the therapeutic effects of high‐frequency rTMS on working memory (WM) and response ...
Mengting Lao, Rongwei Du, Zhujun Wang, Yang Gao, Meiling Cheng, Xianglong Wang, Wen Wu   +6 more
wiley   +1 more source

Analysis of influencing factors on the man-machine system efficiency in high-altitude mines [PDF]

E3S Web of Conferences
High-altitude areas contain a large amount of high-quality mineral resources in China, and the development of mineral resources in these areas has made significant contributions to social and economic development.
Guo Duiming, Xu Hongtu, Pan Weiliang, Li Ningting   +3 more
doaj   +1 more source