Results 91 to 100 of about 6,503,337 (298)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Tigecycline and Overall Mortality [PDF]

Clinical Infectious Diseases, 2012
Dafna, Yahav, Adi, Lador, Mical, Paul, Leonard, Leibovici   +3 more
openaire   +2 more sources

Levels and trends in child mortality

, 2010
The United Nations Inter-agency Group for Child Mortality Estimation (UN-IGME) updates child mortality estimates annually for monitoring progress. This report presents the UN-IGME's latest estimates of under-five, infant and neonatal mortality and ...
World Health Organization, World Bank Group, United Nations, UNICEF   +3 more
core  

Auckland Stress and Support Study, 2013-15 (REACH 03)

, 2019
85 romantic couples (N = 170) from Auckland, New Zealand participated in study examining emotion regulation and support processes when facing significant stressful challenges.
Overall, Nickola
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Global, regional, and national under-5 mortality, adult mortality, age-specific mortality, and life expectancy, 1970-2016: a systematic analysis for the Global Burden of Disease Study 2016 [PDF]

, 2018
Detailed assessments of mortality patterns, particularly age-specific mortality, represent a crucial input that enables health systems to target interventions to specific populations.

core  

A joint frailty model to estimate the recurrence process and the disease-specific mortality process without needing the cause of death.

, 2014
In chronic diseases, such as cancer, recurrent events (such as relapses) are commonly observed; these could be interrupted by death. With such data, a joint analysis of recurrence and mortality processes is usually conducted with a frailty parameter ...
Roch Giorgi, Belot, Aurélien, Remontet, Laurent, CENSUR working survival group, Giorgi, Roch, Virginie Rondeau, Rondeau, Virginie, Laurent Remontet, Aurélien Belot   +8 more
core   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Overall and Disease Related Mortality in Parkinson’s Disease – a Longitudinal Cohort Study

Journal of Parkinson’s Disease, 2019
Background: Earlier research showed that Parkinson’s disease is related to increased overall mortality, but it remains unclear which patient level factors are predictive of increased mortality in Parkinson’s disease.
Jeroen Hoogland, Bart Post, Rob M.A. de Bie   +2 more
doaj   +1 more source

Marital Partner and Mortality: The Effects of the Social Positions of Both Spouses [PDF]

Background Individual education, social class, social status and income are all associated with mortality, and this is likewise the case for the position of the marital partner.
Torssander, Jenny, Erikson, Robert
core