Results 61 to 70 of about 6,503,337 (298)

Venetoclax‐Based Therapy as a Bridge to Hematopoietic Stem Cell Transplantation in Relapsed or Refractory Pediatric Acute Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Relapsed and/or refractory (R/R) pediatric acute leukemia carries a dismal prognosis, largely driven by chemoresistance to conventional salvage therapy. The BH3‐mimetic venetoclax, combined with chemotherapy or hypomethylating agents, has demonstrated efficacy in small clinical trials.
Katherine S. Colman, Deborah Meyran, Vajiranee Malalasekera, Heather Weerdenburg, Janine Campbell, Rachel Conyers, Stacie Wang, Hannah Walker, Seong Lin Khaw, Diane Hanna   +9 more
wiley   +1 more source

Comparative performance and external validation of the multivariable PREDICT Prostate tool for non-metastatic prostate cancer: a study in 69,206 men from Prostate Cancer data Base Sweden (PCBaSe)

BMC Medicine, 2020
Background PREDICT Prostate is an endorsed prognostic model that provides individualised long-term prostate cancer-specific and overall survival estimates. The model, derived from UK data, estimates potential treatment benefit on overall survival.
David Thurtle, Ola Bratt, Pär Stattin, Paul Pharoah, Vincent Gnanapragasam   +4 more
doaj   +1 more source

Differential Mortality Risk by Age in Males and Females With Steatotic Liver Disease

MedComm
Metabolic dysfunction‐associated steatotic liver disease (MASLD) is a major cause of premature mortality, but data on sex differences in mortality remain limited.
Taotao Yan, Nicholas Chien, Vy H. Nguyen, Isaac Le, Surya Teja Gudapati, Angela Chau, Xinrong Zhang, Scott Barnett, Sovann Linden, Linda Henry, Ramsey Cheung, Mindie H. Nguyen   +11 more
doaj   +1 more source

Comparative impact of the affordable care act on breast cancer outcomes among women in two US states

Frontiers in Oncology
IntroductionSince the implementation of the Patient Protection and Affordable Care Act (ACA) and Medicaid expansion, states that adopted the policy have seen reduced uninsured rates.
Oluwasegun Akinyemi, Mojisola Fasokun, Terhas Weldeslase, Eunice Odusanya, Irene Akinyemi, Kailyn Geter, Meghana Akula, Miriam Michael, Kakra Hughes, Robin Williams   +9 more
doaj   +1 more source

Impact of the COVID‐19 pandemic on the mortality among patients with colorectal cancer in Hiroshima, Japan: A large cancer registry study

Cancer Medicine, 2023
Background This retrospective cohort study aimed to evaluate the impact of the COVID‐19 pandemic on colorectal cancer care and mortality using a large cancer registry in Hiroshima Prefecture, Japan.
Daisuke Miyamori, Tsukasa Kamitani, Shuhei Yoshida, Yuya Shigenobu, Kotaro Ikeda, Yuka Kikuchi, Saori Kashima, Yosuke Yamamoto   +7 more
doaj   +1 more source

Effectiveness of Resistance Intradialytic Exercise Compared to Aerobic Intradialytic Exercise for Patients With Chronic Kidney Disease: A Randomized Controlled Clinical Trial

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Patients with chronic kidney disease undergoing hemodialysis commonly experience reduced physical function, fatigue, poor sleep quality, and impaired health‐related quality of life. Intradialytic exercise has been proposed as a non‐pharmacological strategy to improve these outcomes.
Klebson da Silva Almeida, Gisela Cristiane Miyamoto, Daniel da Costa Torres, Ian Setubal Reis Chaves, Jonas do Carmo Paschoalin, Braúlio Lima Nascimento, Luciana Dias Chiavegato   +6 more
wiley   +1 more source

Effect of overall lifestyle on the all-cause mortality and cardiovascular disease death in dyslipidemia patients with or without lipid-lowering therapy: a cohort study

BMC Cardiovascular Disorders, 2023
Background Lifestyle adjustment has been reported as one of the interventions for dyslipidemia. This study aimed to explore the effect of overall lifestyle on the risk of all-cause mortality and cardiovascular disease (CVD) death in dyslipidemia patients
Qian Wang, Dong Pang, Hui Wang
doaj   +1 more source

Serum Myonectin Levels Are Positively Associated With Physical Function and Lower Frailty‐Related Limitation in Maintenance Hemodialysis Patients: A Cross‐Sectional Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Maintenance hemodialysis (MHD) patients frequently suffer from frailty, characterized by reduced physical function and poor prognosis. Myokines, such as myonectin, secreted by muscle, are emerging regulators of systemic health. This study investigated the relationship between serum myonectin, adipokines (adiponectin, omentin), and ...
Kenichi Kono, Yoshifumi Moriyama, Koji Ohashi, Naoya Otaka, Minako Tatsumi, Toyoaki Murohara, Noriyuki Ouchi, Satoru Oshima   +7 more
wiley   +1 more source

Comparative Evaluation of Hemodiafiltration, Hemoperfusion, and Standard Hemodialysis on Efficacy, Inflammatory Control, Dialysis Adequacy, and Safety in End‐Stage Renal Disease: A Prospective Observational Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Chronic micro‐inflammation in patients with end‐stage renal disease (ESRD) is a significant driver of cardiovascular complications and diminished quality of life. While standard hemodialysis (SHD) effectively manages small‐molecule clearance, its ability to remove medium‐to‐large uremic toxins—the primary catalysts of systemic ...
Hongwei Zuo, Weisi Dai, Jie Mao, Mei Ye, Xingshan Lu, Xiaocui Zhang   +5 more
wiley   +1 more source

Health Outcomes Associated with Asymptomatic Toxoplasma gondii Seropositivity in Young Adults: A Nationwide Matched Cohort Study

Microorganisms
Toxoplasma gondii establishes latent infection in a substantial proportion of the global population, yet the long-term health consequences of this infection remain incompletely characterized.
Sarah Israel, Eugene Merzon, Yotam Shenhar, Shai Ashkenazi, Abraham Weizman, Shlomo Vinker, Eli Magen, Ariel Israel   +7 more
doaj   +1 more source