Results 151 to 160 of about 1,740,794 (265)

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Impact of Allostatic Load on Overall Survival in Patients With Endometrial Cancer. [PDF]

Cancer Med
Sinha N, Miller V, Diggs A, Broaddus E, Bae-Jump V, Lara OD.   +5 more
europepmc   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Race and Ethnicity and Overall Survival in Pediatric Acute Myeloid Leukemia.

JAMA Netw Open
Zheng DJ, Khuong L, Aftandilian C, Bona K, Caywood EH, Elgarten CW, Fisher BT, Gathers CL, Ghosh T, Gramatges MM, Hettinger G, Henry MR, Huang YV, Li Y, Maloney K, Mian A, Miller TP, Modi A, Mody R, Myers RM, Newman H, Ortiz J, Seif AE, Smith C, Stokke J, Winick N, Wilkes JJ, Wong V, Aplenc R, Getz KD.   +29 more
europepmc   +1 more source

Treatment Outcomes and Overall Survival of Patients With B-Cell Prolymphocytic Leukemia. [PDF]

EJHaem
Ermann DA, Vardell VA, Fitzgerald L, Bock A, Shah H, Hu B, Stephens DM.   +6 more
europepmc   +1 more source

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

A comparison of overall survival and quality of life in patients with MDS treated with azacytidine vs decitabine. [PDF]

Blood Neoplasia
England JT, Zhang L, Yee K, Geddes M, Zhu N, Shamy A, Leitch H, Sabloff M, Christou G, Houston BL, Landego I, Leber B, Khalaf D, Garcia-Horton A, St-Hilaire E, Finn N, Nevill T, Trottier A, Storring J, Elemary M, Delage R, Habib L, Chodirker L, Chow S, Cheung M, Mozessohn L, Kennedy JA, Buckstein R.   +27 more
europepmc   +1 more source

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

Prostate cancer screening and evidence: the role of overall survival. [PDF]

Transl Androl Urol
Takahashi T.
europepmc   +1 more source

Exploring the influence of lactoferrin on wound healing and related signaling pathways: a systematic review

FEBS Open Bio, EarlyView.
Lactoferrin promotes wound healing by activating MAPK, PI3K/Akt, and extracellular matrix pathways, enhancing fibroblast remodeling, proliferation, and re‐epithelialization. These mechanisms highlight its therapeutic potential in inflammation control, tissue repair, and remodeling.
Morgana Lüdtke Azevedo, Kátia Cristiane Hall, Matheus dos Santos Fernandez, Geovanna Peter Corrêa, Rafael Guerra Lund   +4 more
wiley   +1 more source