Results 161 to 170 of about 1,740,794 (265)

Lung Function-Associated Genetic Variants and Overall Survival in Non-Small Cell Lung Cancer: A Multi-Platform Analysis. [PDF]

Cancer Epidemiol Biomarkers Prev
Li Z, Zhang Z, Zhao YC, Su L, Li Y, Christiani DC.   +5 more
europepmc   +1 more source

From patient advocacy to patient‐driven research: Building active partnerships beginning at the bench to reach the bedside

FEBS Open Bio, EarlyView.
Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia, Rachel Heilmann, Maximiliano Barrientos, Laura MacNeill, Ingrid Vallee, Sarah K. Schultz, Patrick O'Donoghue, Angelica A. Moresco, Victoria M. Siu, Ilka U. Heinemann   +9 more
wiley   +1 more source

DTI-ALPS is not independently associated with overall survival beyond established prognostic factors in glioblastoma. [PDF]

J Neurooncol
Schmidt L, Santaniello SD, Krenzlin H, Kronfeld A, Kollmann B, Tüscher O, Frauenknecht K, Jägersberg M, Altmann S, Brockmann MA, Othman AE.   +10 more
europepmc   +1 more source

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source

Overall survival in oncology phase III trials: an individual patient level meta-analysis (OPTIMA). [PDF]

Oncologist
Sherry AD, Meimoun N, Miller AM, Liu J, Chauhan K, Kouzy R, Lin TA, Msaouel P, Ludmir EB.   +8 more
europepmc   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Intratumoral susceptibility signals in adult-type diffuse gliomas: associations with molecular profile, tumor grade, and overall survival. [PDF]

Front Med (Lausanne)
Feraco P, Giuliani D, Espa G, Gagliardo C, Henssen D, Meijer FJA, Greco V, Bertalot G, Caffo O.   +8 more
europepmc   +1 more source

Salmonella enterica serovar typhi limits the potency of typhoid toxin and ADP‐ribosylating toxin AB to establish a persistent infection

FEBS Open Bio, EarlyView.
The two catalytic subunits of typhoid toxin dissociate from the holotoxin in the ER of an intoxicated cell, but only CdtB exits the ER to generate immunosuppressive effects. PltA is retained in the ER and sequestered from its cytosolic target, thus allowing the anti‐inflammatory effects of CdtB to promote intestinal colonization.
Maria C. Zabala‐Rodriguez, Juliette K. Tinker, Teresa Frisan, Taj Azarian, Ken Teter   +4 more
wiley   +1 more source

Intermediate clinical endpoints as surrogates for overall survival after salvage prostatectomy. [PDF]

BJU Int
Roessler N, Nowicka Z, Miszczyk M, Calleris G, Dematteis A, Vetterlein MW, Albisinni S, Van Der Poel HG, Cathcart P, Cacciamani GE, Gill IS, Persad RA, Joniau S, Sanchez-Salas R, Smith JA, Karnes RJ, Ahmed ME, Rajwa P, Tilki D, Shariat SF, Gontero P, Marra G, Young Academic Urologists Prostate Cancer Working Party.   +22 more
europepmc   +1 more source