Results 191 to 200 of about 1,511,681 (307)

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

The most appropriate category of metastatic lymph nodes to evaluate overall survival of gastric cancer following curative resection [PDF]

, 2008
Jing‐Yu Deng, Han Liang, Dan Sun, Hongjie Zhan, Xiaona Wang   +4 more
openalex   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Association of risk factors for venous thromboembolism and overall survival in lung cancer. [PDF]

Blood Vessel Thromb Hemost
Plate TE, Trabolsi A, Kronenfeld RS, Campoverde LE, Morgenstern-Kaplan D, Mercadel AJ, Caballero M, Zhao W, Soff GA.   +8 more
europepmc   +1 more source

In Patients Experiencing Biochemical Failure After Radiotherapy, Pretreatment Risk Group and PSA Velocity Predict Differences in Overall Survival and Biochemical Failure-Free Interval [PDF]

, 2008
Daniel E. Soto, Rebecca Andridge, Charlie C. Pan, Scott Williams, Jeremy M. G. Taylor, Howard M. Sandler   +5 more
openalex   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Impact of adjuvant chemotherapy delay on overall survival in early-stage breast cancer: a retrospective analysis. [PDF]

Front Oncol
Alhalabi A, Abdo T, Herrán M, Sarna K, Tfayli R, Nahleh Z.   +5 more
europepmc   +1 more source

Relationship of Circulating Tumor Cells to Tumor Response, Progression-Free Survival, and Overall Survival in Patients With Metastatic Colorectal Cancer [PDF]

, 2008
Steven J. Cohen, Cornelis J.A. Punt, Nicholas Iannotti, Bruce Saidman, Kert D. Sabbath, Nashat Gabrail, Joel Picus, Michael Morse, Edith P. Mitchell, Michael Craig Miller, Gerald V. Doyle, H. Tissing, Leon W.M.M. Terstappen, Neal J. Meropol   +13 more
openalex   +1 more source

The rapidly growing landscape of RAS inhibitors: from selective allele blockade to broad inhibition strategies

Molecular Oncology, EarlyView.
RAS‐targeted therapies have become a clinical reality. Although promising results in patients have been achieved, there are still challenges ahead such as coping with drug resistance. Here we summarize selected RAS inhibitors targeting either individual KRAS mutant isoforms (KRASG12C, KRASG12D, KRASG12V) or exhibiting a wider inhibitory spectrum ...
Matthias Drosten, Mariano Barbacid
wiley   +1 more source

Updated Overall Survival and Long-Term Safety With Ripretinib Versus Sunitinib in Patients With GI Stromal Tumor: Final Overall Survival Analysis From INTRIGUE. [PDF]

J Clin Oncol
Heinrich MC, Blay JY, Gelderblom H, George S, Schöffski P, von Mehren M, Zalcberg JR, Jones RL, Kang YK, Razak AA, Trent J, Attia S, Le Cesne A, Boye K, Goldstein D, Sánchez C, Siontis BL, Cox P, Davis E, Sherman ML, Ruiz-Soto R, Bauer S.   +21 more
europepmc   +1 more source