Results 31 to 40 of about 45,763 (274)

Understanding the Overdispersed Molecular Clock [PDF]

Genetics, 2000
Abstract Rates of molecular evolution at some protein-encoding loci are more irregular than expected under a simple neutral model of molecular evolution. This pattern of excessive irregularity in protein substitutions is often called the “overdispersed molecular clock” and is characterized by an index of dispersion, R(T) > 1 ...
openaire   +2 more sources

On the Overdispersed Molecular Clock [PDF]

Genetics, 1987
ABSTRACT Rates of molecular evolution at some loci are more irregular than described by simple Poisson processes. Three situations under which molecular evolution would not follow simple Poisson processes are reevaluated from the viewpoint of the neutrality hypothesis: (i) concomitant or multiple substitutions in a gene, (ii) fluctuating
openaire   +2 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Effect of spatial overdispersion on confidence intervals for population density estimated by spatial capture–recapture

Peer Community Journal
Spatially explicit capture–recapture models are used widely to estimate the density of animal populations. The population is represented by an inhomogeneous Poisson point process, where each point is the activity centre of an individual and density ...
Efford, Murray G., Fletcher, David
doaj   +1 more source

Integrative Analysis of Spatial Heterogeneity and Overdispersion of Crime with a Geographically Weighted Negative Binomial Model

ISPRS International Journal of Geo-Information, 2020
Negative binomial (NB) regression model has been used to analyze crime in previous studies. The disadvantage of the NB model is that it cannot deal with spatial effects.
Jianguo Chen, Lin Liu, Luzi Xiao, Chong Xu, Dongping Long   +4 more
doaj   +1 more source

A Semiparametric Approach to Test for the Presence of INAR: Simulations and Empirical Applications

Mathematics, 2022
The present paper explores the application of bootstrap methods in testing for serial dependence in observed driven Integer-AutoRegressive (models) considering Poisson arrivals (P-INAR).
Lucio Palazzo, Riccardo Ievoli
doaj   +1 more source

Updating predictive accident models of modern rural single carriageway A-roads [PDF]

, 2012
Reliable predictive accident models (PAMs) are essential to design and maintain safe road networks and yet the models most commonly used in the UK were derived using data collected 20 to 30 years ago.
Alan G. Wood, Linda J. Mountain, Mike J. Maher, Richard D. Connors, Turner D. J.   +4 more
core   +1 more source

Developing and Evaluating a Laboratory‐Based Frailty Index (FI‐Lab) for the Prediction of Long‐Term Health Outcomes in Systemic Lupus Erythematosus

Arthritis Care &Research, Accepted Article.
Objective We aimed to construct and evaluate the first laboratory‐based frailty index (FI‐Lab) for predicting adverse outcomes in systemic lupus erythematosus (SLE) and to compare its predictive ability to that of an existing clinical frailty index (FI).
Grace Burns, Samuel D. Searle, Alexandra Legge   +2 more
wiley   +1 more source

Rgbp: An R Package for Gaussian, Poisson, and Binomial Random Effects Models with Frequency Coverage Evaluations

Journal of Statistical Software, 2017
Rgbp is an R package that provides estimates and verifiable confidence intervals for random effects in two-level conjugate hierarchical models for overdispersed Gaussian, Poisson, and binomial data.
Hyungsuk Tak, Joseph Kelly, Carl Morris
doaj   +1 more source

IGF‐1 Deficiency Serves as an Integrated Biomarker Pathogenic Driver and Predictor in Poor Ovarian Response

Advanced Science, EarlyView.
IGF‐1 deficiency underlies poor ovarian response (POR), as reduced levels in follicular fluid and granulosa cells impair antral follicle formation and compromise reproductive outcomes. Including IGF‐1 as a biomarker significantly enhances the accuracy of models predicting both PORrisk and pregnancy success.
Zhu Hu, Yuanyuan Yu, Guanyou Huang, Jinnan Li, Chao Yang, Aizhuan Long, Jia Tang, Tengxiang Chen, Shuyun Zhao, Tuo Zhang   +9 more
wiley   +1 more source