Results 51 to 60 of about 270,274 (308)

Advancements in Dissolving Microneedles for Effective Transdermal Delivery in Rheumatoid Arthritis Treatment

Advanced Materials Interfaces, EarlyView.
Rheumatoid arthritis, a chronic inflammatory joint disease, faces limitations with conventional therapies. Dissolving microneedles (DMNs) enable biocompatible, high‐capacity transdermal drug delivery. However, skin elasticity challenges their strength, limiting drug release depth.
Wangrui Peng, MeeiChyn Goh, Jie Lan, Meng Du, Zhiyi Chen   +4 more
wiley   +1 more source

Ultrashort‐Pulsed Laser Diffusion Enhancement in Liquids for Cold Extraction of Coffee in an Analytically Validated Low‐Fluence Regime

Advanced Photonics Research, EarlyView.
In this article, pulsed laser diffusion enhancement in liquids as an analytically validated laser extraction in liquids method of coffee suspensions in a defined low fluence window is presented. The results confirm the generation of a unique aroma profile and reduced acidity, which is neither attributed to changes in the specific surface area nor ...
Tina Friedenauer, Simela Kordhishte, Wiebke L. M. Narz, Tobias Bessel, Lucie K. Tintrop, Maryam Vosough, Amir Salemi, Cedric Thom, Sven W. Meckelmann, Maximilian Spellauge, Alexander Sommeryns, Christoph Rehbock, Torsten C. Schmidt, Oliver J. Schmitz, Heinz P. Huber, Stephan Barcikowski   +15 more
wiley   +1 more source

Multi‐Material Additive Manufacturing of Soft Robotic Systems: A Comprehensive Review

Advanced Robotics Research, EarlyView.
This review explores the transformative role of multi‐material additive manufacturing (MMAM) in the development of soft robotic systems. It presents current techniques, materials, and design strategies that enable functionally graded and adaptive structures.
Ritik Raj, Quan‐Chen Song, Jia‐Yang Juang   +2 more
wiley   +1 more source

Macrophage‐Mediated Transport of Insoluble Indirubin Induces Hepatic Injury During Intestinal Inflammation

Advanced Science, EarlyView.
Plant‐derived bioactive molecules with low solubility and permeability induce hepatocyte injury, though the mechanisms driving their hepatic effects remain poorly understood. This study identifies a novel transport pathway in which poorly soluble indirubin accumulates in the liver via macrophage‐mediated uptake in Peyer's patches, exacerbating hepatic ...
Yiqi Xu, Jingchun Shi, Heung‐Lam Mok, Cheng Lyu, Junbang Chen, Chunhua Huang, Hongyan Qin, Chengyuan Lin, Hor‐Yue Tan, Zhaoxiang Bian   +9 more
wiley   +1 more source

UFO Presents! A viral hepatitis prevention and education program for young adult IDUs [PDF]

, 2009
UFO Presents! is a Center for Disease Control and Prevention (CDC)-funded program providing much needed hepatitis education, prevention and care services for youth and young adults with injection risk in San Francisco, CA.

core  

Dose Finding with Escalation with Overdose Control (EWOC) in Cancer Clinical Trials

, 2010
Traditionally, the major objective in phase I trials is to identify a working-dose for subsequent studies, whereas the major endpoint in phase II and III trials is treatment efficacy. The dose sought is typically referred to as the maximum tolerated dose
Rogatko, André, Tighiouart, Mourad
core   +1 more source

Characterization of B Cell Responses in Rainbow Trout (Oncorhynchus Mykiss) Affected by Red Mark Syndrome

Advanced Science, EarlyView.
This study extensively characterizes the B cell response of rainbow trout (Oncorhynchus mykiss) in response to red mark syndrome (RMS). This disease, suspected to be caused by a Midichloria‐like organism (MLO), induces skin lesions in the infected animals, characterized by a massive influx of IgM+ B cells.
J Germán Herranz‐Jusdado, Samuel Vicente‐Gil, Esther Morel, Pablo Jiménez‐Barrios, Rocío Simón, Pedro Perdiguero, Diana Martín, Marta Vargas‐Ramírez, Niels Lorenzen, Jacob Günther Schmidt, Carolina Tafalla   +10 more
wiley   +1 more source

USP45 Represses Melanoma Development by Deubiquitinating and Stabilizing Tumor Suppressor MRGPRF

Advanced Science, EarlyView.
USP45 acts as a melanoma suppressor by stabilizing MRGPRF, which weakens the PI3K/AKT pathway, suppresses tumor growth, and reduces melanoma cell migration and invasion. Abstract Melanoma, a highly malignant skin cancer, has seen a rising incidence and death toll. MRGPRF is a novel melanoma suppressor that inhibits the PI3K/AKT pathway.
Wancong Zhang, Liyun Chen, Jing Zhao, Aiwei Ma, Wenqi Shi, Yiwen Zhang, Zixuan Tang, Jiarui Guo, Zaihua Xu, Jianda Zhou, Shijie Tang   +10 more
wiley   +1 more source

Cellular Adaptation to Mechanical Stress Emerges via Cell Shrinkage Triggered by Nonlinear Calcium Elevation

Advanced Science, EarlyView.
Here, a decision‐making mechanism underlying mechanical adaptation is demonstrated. This study demonstrates that cellular adaptation to mechanical stress can be induced by applying low‐amplitude stretch to cells. When the stretch reaches a critical amplitude threshold, it triggers Ca2⁺‐dependent positive feedback, which induces cholesterol efflux and ...
Zhengyan Wang, Zihan Li, Lei Wang, Haitao Zhang, Xiaoshan Yang, Lili Bao, Geng Dou, Lili Ren, Yajing Fu, Lan Li, Shengkai Gong, Yang Zhou, Feng Ding, Lu Yu, Haotian Luo, Yao Liu, Fuyang Zhang, Hui Yu, Siying Liu, Xueming Liu, Fulan Wei, Shiyu Liu   +21 more
wiley   +1 more source

Refractive Index‐Corrected Light‐Sheet Microscopy for Macro‐View Cardiovascular Imaging

Advanced Science, EarlyView.
A refractive index‐corrected light‐sheet fluorescence microscopy system enables macro‐view cardiovascular imaging across organs, adapting to refractive index variations from different optical clearing protocols. By integrating axial sweeping, multi‐view imaging, and a sealed chamber, it extends the field of view, enhances isotropy, and improves safety.
Enbo Zhu, Yaran Zhang, Peng Zhao, Jae Min Cho, Zhaoqiang Wang, Yan‐Ruide Li, Jing Wang, Samuel Margolis, Shaolei Wang, Lili Yang, Alison Chu, Yuhua Zhang, Liang Gao, Tzung K. Hsiai   +13 more
wiley   +1 more source