Results 31 to 40 of about 128,386 (269)

Staying under the Radar? Immigration Effects on Overdose Deaths and the Impact of Sanctuary Jurisdictions

Societies, 2023
Growing political and public rhetoric claim that immigration has contributed to drug crime and the overdose crisis of the 21st century. However, research to date has given little attention to immigration–overdose relationships, and almost no work has ...
Kelly Pierce, Diana Sun, Ben Feldmeyer
doaj   +1 more source

Model‐Driven Optimization of Subcutaneous Polymer Prodrugs Achieves Cancer Remission in Mice

Advanced Healthcare Materials, EarlyView.
A pharmacokinetics/pharmacodynamics (PK/PD) model was developed to evaluate multiple dosing regimens for subcutaneously administered water‐soluble polymer prodrug for cancer therapy. The model enabled prediction of in vivo performance and contributed to the optimization of anticancer efficacy.
Anne Rodallec, Randy Lee, Jingming Cao, Sophie Marolleau, Julien Nicolas, Sébastien Benzekry   +5 more
wiley   +1 more source

New psychoactive substances (NPS) identified in Canada: Results of the online NPS survey (2020–2023)

Emerging Trends in Drugs, Addictions, and Health
Purpose and scope: New psychoactive substances (NPS) are a broad class of compounds that are typically designed to mimic illicit substances and circumvent legislative controls.
Sophie Rymill, Lexy Candler, Pavitra Ramachandran, Chantal Bacev-Giles, Raymond-Jonas Ngendabanka, Stephane Racine, Nancy He, Michelle Ross, Susantha Mohottalage   +8 more
doaj   +1 more source

Implementation and evaluation of interprofessional overdose review team recommendations following intentional or accidental overdose events [PDF]

Mental Health Clinician
Drug overdose death rates in the United States remain high despite efforts to mitigate this risk. Many communities and hospitals across the country have implemented overdose review teams, including local overdose fatality review teams or postoverdose ...
Monica Barrett, PharmD, BCPP, Sarah Kemerer, PharmD, Michelle Colvard, PharmD, BCPP   +2 more
doaj   +1 more source

3D Soft Hydrogels Induce Human Mesenchymal Stem Cells “Deep” Quiescence

Advanced Healthcare Materials, EarlyView.
Three‐dimensional soft hydrogels mimicking the bone marrow niche induce deep quiescence in human mesenchymal stem cells. Unlike 2D culture, 3D matrices halt proliferation, regulate cell‐cycle and quiescence markers, and downregulate mTORC1 signaling, preserving stem cell phenotype and therapeutic potential ex vivo.
David Boaventura Gomes, Timo Rademakers, Ana Filipa Henriques Lourenço, Andrea Calore, Clarissa Tomasina, Denis van Beurden, Jinjie Venema, Bryan Chömpff, Hong Liu, Nicole Bouvy, Sandra Camarero‐Espinosa, Lorenzo Moroni   +11 more
wiley   +1 more source

Overdose prevention activities led by local public health departments, 2019–2023

Substance Abuse Treatment, Prevention, and Policy
Background Drug overdose deaths in the United States increased to historic levels in recent years, with provisional estimates indicating more than 111,000 deaths in the 12 months ending July 2023. In 2019, the Centers for Disease Control and Prevention’s
April Wisdom, Stephanie Haddad, Madhumita Govindu, Francis Higgins, Nikki Filion, Kate Sullivan, Cherie Rooks-Peck   +6 more
doaj   +1 more source

Overdose experiences among injection drug users in Bangkok, Thailand

Harm Reduction Journal, 2010
Background Although previous studies have identified high levels of drug-related harm in Thailand, little is known about illicit drug overdose experiences among Thai drug users.
Wood Evan, Kaplan Karyn, Suwannawong Paisan, Hayashi Kanna, Fairbairn Nadia, Milloy M-J, Kerr Thomas   +6 more
doaj   +1 more source

Bacteria‐Responsive Nanostructured Drug Delivery Systems for Targeted Antimicrobial Therapy

Advanced Materials, EarlyView.
Bacteria‐responsive nanocarriers are designed to release antimicrobials only in the presence of infection‐specific cues. This selective activation ensures drug release precisely at the site of infection, avoiding premature or indiscriminate release, and enhancing efficacy.
Guillermo Landa, Gracia Mendoza, Silvia Irusta, Manuel Arruebo   +3 more
wiley   +1 more source

Loperamide Overdose [PDF]

Cureus, 2019
In light of the opioid epidemic, cardiac complications following a loperamide overdose are a growing concern for patients presenting to the emergency department (ED). Here, we present the case of a 35-year-old male with long QT syndrome who presented following a loperamide overdose and was receiving multiple shocks because of the resulting arrhythmias ...
Arnold, Casey, Martinez Martinez, Carmen J   +1 more
openaire   +2 more sources

Vat Polymerization 3D Printing for Controlled Drug Release Applications

Advanced Materials Technologies, EarlyView.
ABSTRACT Vat polymerization (VP) 3D printing, a light‐based additive manufacturing technique, has emerged as a promising technique for fabricating complex drug delivery systems with high precision and spatial resolution. This layer‐by‐layer manufacturing process enables the creation of intricate geometries and customizable architectures, which are ...
Hafiz Busari, O. Thompson Mefford, M. Aaron Vaughn   +2 more
wiley   +1 more source