Results 41 to 50 of about 130,381 (267)

Flash Assembloids: A Rapid Biofabrication of a Platform for Modeling Early Glioblastoma Invasion at the Glioblastoma–Brain Organoid Interfaces

Advanced Healthcare Materials, EarlyView.
This study presents a bioengineered assembloid (ASM) system combining glioblastoma (GBM) cells in oxidized alginate (OA) microgels with dorsal organoids (DOs). This model simulates brain tumor‐host interactions, revealing enhanced GBM invasion, altered gene expression, and aggressive infiltration patterns, demonstrating ASM as a valuable platform for ...
Chao Liang, Henry Robert Howard, Shihui Chen, Won‐Young Choi, Summer Cao, Arthur Chien, Kevin Zou, Michael Kassiou, Fabien Delerue, Ho Sang Jung, Yeonju Park, Young Mee Jung, Yong‐Dae Kwon, Karrie M. Kiang, Gilberto Ka‐Kit Leung, Ryohichi Sugimura, Ann‐Na Cho, Sang Jin Lee   +17 more
wiley   +1 more source

Bacteria‐Responsive Nanostructured Drug Delivery Systems for Targeted Antimicrobial Therapy

Advanced Materials, EarlyView.
Bacteria‐responsive nanocarriers are designed to release antimicrobials only in the presence of infection‐specific cues. This selective activation ensures drug release precisely at the site of infection, avoiding premature or indiscriminate release, and enhancing efficacy.
Guillermo Landa, Gracia Mendoza, Silvia Irusta, Manuel Arruebo   +3 more
wiley   +1 more source

Patterns of health care utilization among people who overdosed from illegal drugs: a descriptive analysis using the BC Provincial Overdose Cohort

Health Promotion and Chronic Disease Prevention in Canada, 2018
Introduction: British Columbia (BC) declared a public health emergency in April 2016 in response to a rapid rise in overdose deaths. Further understanding of health care utilization is needed to inform prevention strategies for individuals who overdose ...
Michael C. Otterstatter, Alexis Crabtree, Sabina Dobrer, Brooke Kinniburgh, Salman Klar, Anthony Leamon, Jennifer May-Hadford, Christopher Mill, Mina Park, Andrew W. Tu, Lu Zheng   +10 more
doaj   +1 more source

Minimally Invasive Delivery of Optical Nanosensors Using Injectable Hydrogels

Advanced Materials Interfaces, EarlyView.
Injectable peptide hydrogels offer a minimally invasive delivery platform for single‐walled carbon nanotube (SWCNT)‐based near‐infrared fluorescent sensors, enabling real‐time measurement of drug concentrations. Encapsulated SWCNTs show a dose‐dependent fluorescence response across physiologically relevant concentrations and retain their fluorescence ...
Shirel Kleiner, Gili Bisker
wiley   +1 more source

New psychoactive substances (NPS) identified in Canada: Results of the online NPS survey (2020–2023)

Emerging Trends in Drugs, Addictions, and Health
Purpose and scope: New psychoactive substances (NPS) are a broad class of compounds that are typically designed to mimic illicit substances and circumvent legislative controls.
Sophie Rymill, Lexy Candler, Pavitra Ramachandran, Chantal Bacev-Giles, Raymond-Jonas Ngendabanka, Stephane Racine, Nancy He, Michelle Ross, Susantha Mohottalage   +8 more
doaj   +1 more source

Implementation and evaluation of interprofessional overdose review team recommendations following intentional or accidental overdose events [PDF]

Mental Health Clinician
Drug overdose death rates in the United States remain high despite efforts to mitigate this risk. Many communities and hospitals across the country have implemented overdose review teams, including local overdose fatality review teams or postoverdose ...
Monica Barrett, PharmD, BCPP, Sarah Kemerer, PharmD, Michelle Colvard, PharmD, BCPP   +2 more
doaj   +1 more source

TRMT6‐Mediated m1A Modification of CDK9 mRNA Is a Dual‐Pronged Pathogenic Driver for HBV‐Related Hepatocellular Carcinoma

Advanced Science, EarlyView.
TRMT6‐mediated m1A modification in CDK9 mRNA enhances its mRNA stability and translation efficiency, thereby increasing the protein levels of CDK9. Upregulated CDK9 promotes the progression of HCC by elevating the levels of oncogenic factors including p‐STAT3, MCL1, and BCL‐2. On the other hand, CDK9 phosphorylates TARDBP at Ser254 to activate HBV core
Rui Zhang, Dandan Zong, Rui Liu, Yubo Wang, Qingqing Gu, Yao Yao, Wenfang Zheng, Mengmeng Yuan, Simeng Wang, Rongrong Cui, Daxu Li, Siwen Dang, Peng Hou   +12 more
wiley   +1 more source

Overdose prevention activities led by local public health departments, 2019–2023

Substance Abuse Treatment, Prevention, and Policy
Background Drug overdose deaths in the United States increased to historic levels in recent years, with provisional estimates indicating more than 111,000 deaths in the 12 months ending July 2023. In 2019, the Centers for Disease Control and Prevention’s
April Wisdom, Stephanie Haddad, Madhumita Govindu, Francis Higgins, Nikki Filion, Kate Sullivan, Cherie Rooks-Peck   +6 more
doaj   +1 more source

Opioid Education and Nasal Naloxone Rescue Kits in the Emergency Department

Western Journal of Emergency Medicine, 2015
Introduction: Emergency departments (EDs) may be high-yield venues to address opioid deaths with education on both overdose prevention and appropriate actions in a witnessed overdose.
Dwyer, Kristin , Walley, Alexander Y. , Langlois, Breanne K. , Mitchell, Patricia M. , Nelson, Kerrie P. , Cromwell, John, Bernstein, Edward   +6 more
doaj   +1 more source

Staying under the Radar? Immigration Effects on Overdose Deaths and the Impact of Sanctuary Jurisdictions

Societies, 2023
Growing political and public rhetoric claim that immigration has contributed to drug crime and the overdose crisis of the 21st century. However, research to date has given little attention to immigration–overdose relationships, and almost no work has ...
Kelly Pierce, Diana Sun, Ben Feldmeyer
doaj   +1 more source