Results 241 to 250 of about 746,175 (357)

Drug‐Induced Cuproptosis Defines the Therapeutic Window of Celecoxib in Intervertebral Disc Degeneration via the HSP90‐RBX1 Axis

Advanced Science, EarlyView.
This study reveals the dual role of celecoxib in intervertebral disc degeneration. While low concentrations are protective, high concentrations induce toxicity by upregulating HSP90, which synergizes with USP15 to deubiquitinate and stabilize RBX1. This leads to degradation of COMMD1/ATP7B, copper dyshomeostasis, and ultimately, cuproptosis.
Youfeng Guo, Hongju Xiao, Shenghao Ba, Yu Zhou, Bijun Wang, Bin Yu, Yufeng Huang, Haihong Zhao, Zhefan Stephen Chen, Na Shen, Zhaoyu Ba, Desheng Wu   +11 more
wiley   +1 more source

Fetuin-b Mediates Lipid Overload-Induced Hepatic Lipid Accumulation in Large Yellow Croaker (Larimichthys crocea). [PDF]

FASEB J
Shen Y, Chen Q, Zhao Z, Chen Q, Tang Y, Chen F, Hao T, Du J, Ai Q.   +8 more
europepmc   +1 more source

Microsphere‐Modulated Sensing‐in‐Energy Supercapacitor With Self‐Filtering Ultra‐Large Signal Under High‐g Shocks

Advanced Science, EarlyView.
To overcome severe signal oscillation under extreme impact conditions, this work presents a Sensing‐in‐Energy microdevice which integrates a MEMS inertial structure directly within a supercapacitor electrolyte cavity. Utilizing shock‐driven transient contact and electrolyte damping for signal self‐filtering, it achieves weak‐oscillation, large ...
Zhihao Zheng, Yiqun Wang, Kaiyou Liu, Shancheng Luan, Yajiang Yin, Xiaofeng Wang, Keren Dai, Zheng You   +7 more
wiley   +1 more source

Iron overload disrupts lipid desaturation through SKN-1 signaling in <i>C. elegans</i>: implications for ferroptosis-based immunomodulatory biomaterials. [PDF]

Mater Today Bio
Dong Z, Liao Y, Shi H, Zhang J, Lin J, Liu Q, Zhang S, Fan X, Liu B, Wang Y, Zheng Y, Gao L.   +11 more
europepmc   +1 more source

The effect of location on closure measurements after overloads

, 1989
X. Su, W. N. Sharpe
openalex   +1 more source

CD44‐Targeting Hydroxyapatite Nanoparticles (HAP) Induce Mitochondrial Dysfunction‐Driven PANoptosis and Immunogenic Cell Death (ICD) via Ca Overload in Colorectal Cancer

Advanced Science, EarlyView.
ABSTRACT Colorectal cancer (CRC) remains therapeutically challenging due to high metastasis, recurrence, and immunotherapy resistance driven by tumor microenvironment‐mediated immune evasion. Immunogenic cell death (ICD) offers a promising strategy to reshape the immune microenvironment, yet existing ICD inducers suffer from poor targeting efficiency ...
Yao Xiao, Yuxuan Yang, Haosen Qiu, Jia Yang, Hao Liang, Zhaojun Jiang, Xiao Tong, Yongying Li, Qunfeng Huang, Jiaming Wu, Tian Lin, Jiang Yu, Min Liang   +12 more
wiley   +1 more source

Management Strategies for Congestive Heart Failure in Chronic Kidney Disease: Narrative Review. [PDF]

Biomedicines
Soto-Santillan P, Jacobo-Ruvalcaba A, Wasung-de Lay ME, Orihuela-Rodriguez O.   +3 more
europepmc   +1 more source

H2S‐Amplified “Three‐in‐One” Antibacterial Strategy for Periodontitis Treatment Using a Photosensitive Pillararene‐Embedded COF/MOF Hybrid

Advanced Science, EarlyView.
The integration of ROS‐generating systems with H2S depletion strategies effectively overcomes the limitations imposed by endogenous antioxidant defenses on ROS‐based antimicrobial therapies. In this study, the Cu‐MOF is incorporated into pillararene‐embedded COF, achieving a “three‐in‐one” antimicrobial effect that markedly alleviated periodontal ...
Shuang Liang, Meng‐Hao Li, Liang Cheng, Tian‐Shou Zhang, Hui Hui, Yan Wang, Hong‐Pu Zhang, Bo‐Wen Liu, Lin Wang, Ying‐Wei Yang   +9 more
wiley   +1 more source

Utility of Native T1 Mapping for the Evaluation of Myocardial Iron Overload in Patients with Thalassemia Major. [PDF]

Tomography
Amadu AM, Contena A, Dessì A, Piscopo L, Solinas E, Turilli D, Fanni SC, Scaglione M, Masala S.   +8 more
europepmc   +1 more source

Minimalism as a strategy for overcoming information overload of interface design for interactive city devices

, 2020
Varvara E. Ryabinina-Zadernovskaya
openalex   +1 more source