Results 71 to 80 of about 192,860 (277)

TRENDS IN TOURISM DEMAND IN THE TOP VISITED EUROPEAN COUNTRIES [PDF]

Scientific Papers Series : Management, Economic Engineering in Agriculture and Rural Development, 2017
The paper aimed to analyze the main trends in tourism demand in the top European countries in terms of tourist arrivals, overnight stays, tourism intensity, receipts, receipts/arrival, receipts/inhabitant.
Agatha POPESCU
doaj  

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Monetary Policy Implementation and Overnight Rate Persistence [PDF]

Overnight money market rates are the predominant operational target of monetary policy. As a consequence, central banks have re- designed the implementation of monetary policy to keep the deviations of the overnight rate from the key policy rate small ...
Dieter Nautz, Jan Scheithauer
core  

Analyzing the Concentration of Overnight Stays in Constanta City, over the Period 2010-2016 [PDF]

Ovidius University Annals: Economic Sciences Series, 2017
In tourism literature, seasonality is approached as an evolution mode of the activity and, inmost cases, it is seen as a problem faced by tourist destinations/ units, but also by other economicand social agents connected to the tourism activity ...
Jugănaru Mariana, Jugănaru Ion Dănut, Aivaz Kamer Ainur   +2 more
doaj  

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

FEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil, Jeffrey A. Hawkes, Cecilia Blikstad, Pia Lindberg   +3 more
wiley   +1 more source

Combining liquidity usage and interest rates on overnight loans: an oversight indicator [PDF]

This study utilises payment system data to analyse market participants’ liquidity usage and to trace interest rates paid on overnight loans. Our aim is to examine how liquidity usage has changed during the years 2006–2/2011 and to combine this ...
Snellman, Heli, Nummelin, Tuomas, Laine, Tatu   +2 more
core  

Overnight stay in Spanish emergency departments and mortality in older patients

Internal and Emergency Medicine
Abstract OBJECTIVE: To assess whether older adults who spend a night in emergency departments (ED) awaiting admission are at increased risk of mortality. METHODS: This was a retrospective review of a multipurpose cohort that recruited all patients ≥75 years who visited ED and were admitted to hospital on April 1 to 7, 2019, at 52 EDs across ...
Òscar Miró, Sira Aguiló, Aitor Alquézar-Arbé, Cesáreo Fernandez, Guillermo Burillo, Sergio Guzmán Martínez, Maria Esther Martínez Larrull, Andrea B. Bravo Periago, Claudia Lorena Amarilla Molinas, Carolina Rangel Falcon, Paz Balado Dacosta, Rudiger Carlos Chávez Flores, Jorge Navarro Calzada, Eva Maria Fragero Blesa, Manuel Ángel Palomero Martín, Ángela Cobos Requena, Lidia Fuentes, Isabel Lobo Cortizo, Pablo Gonzalez Garcinuño, María Bóveda García, Pedro Rivas Del Valle, Raquel Benavent Campos, Verónica Castro Jiménez, Vanesa Abad Cuñado, Olga Trejo Gutiérrez, María del Mar Sousa Reviriego, Melanie Roussel, Juan González Del Castillo   +27 more
openaire   +3 more sources

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source