Results 41 to 50 of about 419 (262)

Exact Discrete Stochastic Simulation With Deep‐Learning‐Scale Gradient Optimization

Advanced Science, EarlyView.
A 203,796‐parameter gene regulatory network classifies handwritten digits with 98.4% accuracy using exact stochastic dynamics. The framework decouples forward simulation from backward differentiation, making continuous‐time Markov chain models compatible with deep‐learning optimization.
Jose M. G. Vilar, Leonor Saiz
wiley   +1 more source

Chromatin Packing Domain Engineering Through the Manipulation of Nuclear Cationic States

Advanced Science, EarlyView.
Manipulation of intranuclear divalent cation concentrations rapidly and reversibly remodels chromatin packing domains in living cells. Magnesium depletion disrupts domain compaction, heterochromatin organization, and transcriptional regulation, whereas magnesium loading promotes more compact and stable domains.
Cody L. Dunton, Carrillo Paola Gonzalez, Luay Almassalha, Wing Shun Li, Ruyi Gong, Nicolas Acosta, I Chae Ye, Jane Frederick, Christopher Hogg, Saira John, J. A. Gareth Williams, Rikkert J. Nap, Igal Szleifer, Vadim Backman   +13 more
wiley   +1 more source

Numerical Simulation of the Unsteady Airwake of the Liaoning Carrier Based on the DDES Model Coupled with Overset Grid

Journal of Marine Science and Engineering
The wake behind an aircraft carrier under heavy wind condition is a key concern in ship design. The Chinese Liaoning ship’s upturned bow and the island on the deck could cause serious flow separation in the landing and take-off area.
Xiaoxi Yang, Baokuan Li, Zhibo Ren, Fangchao Tian   +3 more
doaj   +1 more source

Numerical Simulation of Ship Oil Spill in Arctic Icy Waters

Applied Sciences, 2020
This paper presents a three-dimensional numerical simulation model of an oil spill for application in emergency treatment methods under icy water conditions.
Wei Li, Xiao Liang, Jianguo Lin, Ping Guo, Qiang Ma, Zhenpeng Dong, Jiamin Liu, Zhenhe Song, Hengqi Wang   +8 more
doaj   +1 more source

Sticker Valence Governs Chain Collapse and Liquid‐Liquid Phase Separation in Peptide‐Inspired Associative Polymers

Advanced Science, EarlyView.
Peptide‐inspired associative polymers with arginine‐like guanidinium stickers and lysine‐like ammonium spacers undergo chain collapse and liquid‐liquid phase separation induced by reversible sticker associations. Sticker valence and tunable association strength jointly control the phase behavior, chain conformation, and interfacial cohesion of these ...
Seung‐Hwan Oh, Jinhoon Lee, Seunghyun Lee, Raehyun Jung, Sangyeop Lee, Su‐Mi Hur, Dong Woog Lee, Soo‐Hyung Choi   +7 more
wiley   +1 more source

Time-Spectral Rotorcraft Simulations on Overset Grids [PDF]

32nd AIAA Applied Aerodynamics Conference, 2014
The Time-Spectral method is derived as a Fourier collocation scheme and applied to NASA's overset Reynolds-averaged Navier-Stokes (RANS) solver OVERFLOW. The paper outlines the Time-Spectral OVERFLOWimplementation. Successful low-speed laminar plunging NACA 0012 airfoil simulations demonstrate the capability of the Time-Spectral method to resolve the ...
Joshua I. Leffell, Scott M. Murman, Thomas H. Pulliam   +2 more
openaire   +1 more source

AS‐pHopt: An Optimal pH Prediction Model Enhanced by Active Site of Enzymes

Advanced Intelligent Discovery, EarlyView.
To address the low accuracy of enzyme optimal pH (pHopt) prediction, this study develops active site‐based pHopt (AS‐pHopt), a prediction model enhanced by active site information and pseudo‐label prediction. Integrating key structural and physicochemical features affecting enzyme pHopt, AS‐pHopt uses Evolutionary Scale Modeling (ESM)‐2 with active ...
Wenxiang Song, Xinmin Li, Hongbo Yu, Le Xiong, Guixia Liu, Weihua Li, Yun Tang   +6 more
wiley   +1 more source

Large‐Scale Machine Learning to Screen for Small‐Molecule Senolytics

Advanced Intelligent Discovery, EarlyView.
A consistent workflow underpins all experiments in this study. A dedicated model‐selection dataset first identifies optimal hyperparameters for each algorithm. Models are then trained and rigorously evaluated on independent sets of molecules using the senolytic ratio SR. Comprehensive hyperparameter exploration across SMILES representations, task types,
Alexis Dougha, Jesus Gil, Pedro J. Ballester   +2 more
wiley   +1 more source

Numerical Investigation of the Effect of Spray Rail Designs on the Slamming Behaviour of Planing Hulls [PDF]

Journal of Applied Fluid Mechanics
Slamming loads represent a major design and operational challenge for planing hulls due to their influence on structural integrity and crew comfort.
M. Mohsin, N. M. R. Shaharuddin, M. A. A. Hasnan, M. H. S. Abdol Azis, O. Yaakob, A. Trimulyono   +5 more
doaj   +1 more source

CFD study to predict the effect of a passing ship on moored ships in a confined waterway

International Journal of Naval Architecture and Ocean Engineering, 2023
This study aims to present a practical practice to obtain a reliable numerical solution based on an Unsteady Reynolds Averaged Navier-Stokes (URANS) Computational Fluid Dynamics (CFD) to estimate the forces acting on moored ships during a passage of a ...
Chang Seop Kwon, Seong Mo Yeon
doaj   +1 more source