Results 51 to 60 of about 165,306 (264)

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

open access: yesFEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai   +4 more
wiley   +1 more source

Constitutional control work of the executive authority comparative study with the Lebanese legislation [PDF]

open access: yesمجلة الاجتهاد للدراسات القانونية والاقتصادية, 2019
The acts of the executive authority are administrative acts issued by the president of the republic or by the Prime Minister. These include orders and decrees which are subject to appeal or notice thereof.
Ilyes Djouadi
doaj  

Allies in Transparency? Parliamentary, Judicial and Administrative Interplays in the EU’s International Negotiations

open access: yesPolitics and Governance, 2017
International negotiations are an essential part of the European Union’s (EU) external affairs. A key aspect to negotiations is access to and sharing of information among the EU institutions involved as well as to the general public.
Vigjilenca Abazi, Johan Adriaensen
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

open access: yesFEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto   +3 more
wiley   +1 more source

Judicial Review as an Accountability Mechanism in South Africa: A Discourse on the Nkandla Case

open access: yesAfrican Journal of Inter-Multidisciplinary Studies, 2022
Separation of powers among the three branches of government, in most Constitutional democracies, is a design to avert the tyranny of a personalized rule.
Omololu Michael Fagbadebo   +1 more
doaj  

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

open access: yesFEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas   +6 more
wiley   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

open access: yesFEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Current practice and perspectives in CRO oversight based on a survey performed among members of the German Association of Research-Based Pharmaceutical Companies (vfa)

open access: yesGMS German Medical Science, 2017
In recent years, the number and scope of outsourced activities in the pharmaceutical industry have increased heavily. In addition, also the type of outsourcing has changed significantly in that time.
Hennig, Michael   +6 more
doaj   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

open access: yesFEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace   +6 more
wiley   +1 more source

Shariah governance effects on cash holdings under sustainability commitments: Indonesian Islamic banks [PDF]

open access: yesBanks and Bank Systems
Type of the article: Research Article AbstractThis study investigates the link between sustainability commitment and cash holdings and assesses the relationship between board meetings (BM), industry knowledge (IK), and Shariah Supervisory Boards (SSBs ...
Tettet Fitrijanti   +3 more
doaj   +1 more source

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