Results 91 to 100 of about 6,251,767 (305)

An overview of the theory of irreducible continua [PDF]

, 1933
Bronisłav Knaster
openalex   +1 more source

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

Molecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu, Ning Ding, Xiaobo Xu, Yedan Chen, Yong Zhang, Jingwen Liu, Jiebai Zhou, Hairong Bao, Donghui Zhang, Yijun Song, Yang Shao, Yuanlin Song   +11 more
wiley   +1 more source

Repetitive transcranial magnetic stimulation for Alzheimer’s disease: an overview of systematic reviews and meta-analysis

Frontiers in Aging Neuroscience
ObjectiveAlzheimer’s disease (AD) is a prevalent neurodegenerative condition that significantly impacts both individuals and society. This study aims to evaluate the effectiveness of repetitive transcranial magnetic stimulation (rTMS) as a treatment for ...
Hua Xue, Ya-xin Li, Ya-song Xiao, Wen-hui Fan, Hong-xian He   +4 more
doaj   +1 more source

An overview of photographic monitoring of Finsler's comete (1937 f.) on the Žalov observatory [PDF]

, 1938
Jaroslav Štěpánek
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Editor’s Overview [PDF]

International Productivity Monitor, 2000
This third issue of the International Productivity Monitor produced by the Centre for the Study of Living Standards contains six articles that deal with a wide range of issues in the productivity area. Topics covered are: the contribution of the information and communications technology sector to productivity growth in Canada and the United States; the
openaire   +23 more sources

Targeted protein degradation in oncology: novel therapeutic opportunity for solid tumours?

Molecular Oncology, EarlyView.
Current anticancer therapies are limited by the occurrence of resistance and undruggability of most proteins. Targeted protein degraders are novel, promising agents that trigger the selective degradation of previously undruggable proteins through the recruitment of the ubiquitin–proteasome machinery. Their mechanism of action raises exciting challenges,
Noé Herbel, Sophie Postel‐Vinay
wiley   +1 more source

Lifestyle intervention Tai Chi for adult patients with type 2 diabetes mellitus: a PRIO-harms based overview of 17 systematic reviews

Frontiers in Endocrinology
ObjectiveTo systematically summarize current evidence and determine the clinical effectiveness and safety of Tai Chi for type 2 diabetes mellitus (T2DM) in adults by conducting an overview of systematic reviews (SRs).MethodsA systematic search ...
Furong Zhang, Xixi Chen, Xicen Liu, Xiaoyu Shen, Tianyu Liu, Fang Zeng, Rongjiang Jin   +6 more
doaj   +1 more source

A brief overview of scientific works of Karel Petr [PDF]

, 1938
Vladimír Kořínek
openalex   +1 more source

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

Molecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu, Katherine Eason, Suet‐Feung Chin, Paul A. W. Edwards, Raquel Manzano Garcia, Richard Moulange, Jia Wern Pan, Soo Hwang Teo, Sach Mukherjee, Maurizio Callari, Carlos Caldas, Stephen‐John Sammut, Oscar M. Rueda   +12 more
wiley   +1 more source

An overview [PDF]

, 1934
J. Kroupa
openalex   +1 more source