Longitudinal associations between diet quality, sedentary behaviours and physical activity and risk of overweight and obesity in preschool children: The ToyBox‐study [PDF]
, 2023 María L. Miguel‐Berges +11 more
openalex +1 more source
Advanced Science, EarlyView.Women with overweight or obesity follow intended isocaloric early and late time‐restricted eating (TRE) in a crossover trial. Shotgun plasma lipidomics reveals no significant differences between interventions, but identify pronounced lipid changes—including reductions in ceramides and phosphatidylcholines—within the early TRE.
Kristof Szekely +15 more
wiley +1 more source
Integrative Omics Reveal Female‐Specific Benefits of p16+ Cell Clearance in Aging Mice
Advanced Science, EarlyView.Aging causes accumulation of p16⁺ senescent cells that promote inflammation and dysfunction. Multi‐omics analyses reveal striking sex differences in senescent cell burden and clearance: females accumulate more p16⁺ cells, especially in the liver, and their removal rejuvenates molecular and functional profiles.
Yao Lin +4 more
wiley +1 more source
Human embryos from overweight and obese women display phenotypic and metabolic abnormalities [PDF]
, 2014 STUDY QUESTION Is the developmental timing and metabolic regulation disrupted in embryos from overweight or obese women? SUMMARY ANSWER Oocytes from overweight or obese women are smaller than those from women of healthy weight, yet post-fertilization ...
Leary, C. +5 more
core +1 more source
Advanced Science, EarlyView.Super‐resolution microscopy identifies nano‐sized tau aggregates (nano‐aggregates) and reveals distinct transitions in their morphology and phosphorylation profiles across control, Primary Age‐Related Tauopathy, and Alzheimer's disease brains. Morphology and hyperphosphorylation signatures distinguish physiological from pathological forms, with nano ...
Adriana N. Santiago‐Ruiz +5 more
wiley +1 more source
Use of International Classification of Diseases, Ninth Revision Codes for Obesity: Trends in the United States from an Electronic Health Record-Derived Database. [PDF]
, 2018 Obesity is a potentially modifiable risk factor for many diseases, and a better understanding of its impact on health care utilization, costs, and medical outcomes is needed.
Crawford, Albert +4 more
core +1 more source
Discriminação baseada no peso: representações sociais de internautas sobre a gordofobia [PDF]
, 2018 The concept of fat phobia has been usually used to define ways of discrimination towards overweight bodies. The present work aimed to know the social representations of fat phobia elaborated by internet users. A documental research was conducted based on
Alberto, Maria de Fátima Pereira +4 more
core +1 more source
Lactylation‐Driven YTHDC1 Alleviates MASLD by Suppressing PTPN22‐Mediated Dephosphorylation of NLRP3
Advanced Science, EarlyView.In MASLD, YTHDC1 undergoes increased lactylation and ubiquitination, reducing its expression. AARS1 mediates lactylation at lysine 565, while disrupted binding to LDHA further promotes lactylation, suppressing YTHDC1. This downregulation enhances PTPN22 mRNA stability, leading to NLRP3 dephosphorylation and activation, which exacerbates inflammation ...
Feng Zhang +16 more
wiley +1 more source
BMI-For-Age Cut-Off as an Indicator of Adiposity among In-School Children (Age 4-11 Years) in Obio/Akpor LGA, Rivers State, Nigeria [PDF]
, 2017 Background: Childhood overweight and obesity has been an issue of great concern to developing and developed nation where as degenerative underweight has ravaged the underdeveloped and war turn countries.
Aigbogun EO Jr, Ibeachu PC, Ikechukwu E
core +1 more source
Advanced Science, EarlyView.Cancer cells drive adjacent adipose tissue to release fatty acids by secreting CCL2, which activates PPARα‐dependent lipolysis. The resulting fatty acid influx amplifies HIF‐1α/CCL2 signaling, establishing a positive feedback loop that fuels tumor growth.
Jeong‐Eun Yun +9 more
wiley +1 more source