Results 91 to 100 of about 36,935 (226)

The role of fenestration in acute canine thoracolumbar intervertebral disc extrusion: Part 2—The biological and biomechanical effects of fenestration

Veterinary Surgery, EarlyView.
Abstract Background Prophylactic fenestration is widely performed to prevent recurrence of canine acute thoracolumbar intervertebral disc extrusion (IVDE); however, there is a paucity of specific data regarding the biological and biomechanical effect of this procedure on the intervertebral disc and vertebral column.
James D. Crowley, Paul Freeman, William R. Walsh   +2 more
wiley   +1 more source

Effects of tempol on renal medullary tissue hypoxia in an ovine model of Gram‐negative septic acute kidney injury

Experimental Physiology, EarlyView.
Abstract Renal arterial infusion of tempol (RAT) at the onset of Gram‐negative sepsis can prevent sepsis‐induced medullary tissue hypoxia and acute kidney injury (AKI). However, it is not known whether treatment with tempol at a clinically relevant time point of sepsis is similarly effective. Thus, we examined whether tempol can reverse renal medullary
Rachel Peiris, Anton Trask‐Marino, Alemayehu Jufar, Ashenafi H. Betrie, Adam Southon, Sally G. Hood, Rinaldo Bellomo, Abraham H. Hulst, Clive N. May, Connie P. C. Ow, Yugeesh R. Lankadeva   +10 more
wiley   +1 more source

A new approach to an old disease: Ageing, arrhythmogenic substrate and the role of risk‐factor modification in atrial fibrillation

Experimental Physiology, EarlyView.
Abstract Atrial fibrillation (AF) prevalence rises sharply with age due to two independent mechanisms. Ageing produces irreversible arrhythmogenic substrate changes through progressive fibrosis, cellular senescence and mitochondrial dysfunction, while modifiable risk factors such as obesity, hypertension, sleep apnoea, diabetes and alcohol use promote ...
Udit Thakur, Jonathan M. Kalman
wiley   +1 more source

Placental mitochondrial metabolic adaptation maintains cellular energy balance in pregnancy complicated by gestational hypoxia

The Journal of Physiology, EarlyView.
Abstract figure legend Placental mitochondrial adaptation to gestational hypoxia. Hypoxic pregnancy in sheep increases placental insulin like growth factor 2 (IGF2) signalling (1), which is associated with a shift in capacity away from β‐oxidation (2) and complex I‐mediated respiration (3), while maintaining total oxidative phosphorylation capacity (4).
Wen Tong, Beth J. Allison, Kirsty L. Brain, Olga V. Patey, Youguo Niu, Kimberley J. Botting, Sage G. Ford, Tess A. Garrud, Peter F. B. Wooding, Qiang Lyu, Lin Zhang, Jin Ma, Alice P. Sowton, Katie A. O'Brien, Tereza Cindrova‐Davies, Hong Wa Yung, Graham J. Burton, Andrew J. Murray, Dino A. Giussani   +18 more
wiley   +1 more source

Multiscale four‐dimensional imaging of cardiac remodelling after myocardial infarction

The Journal of Physiology, EarlyView.
Abstract figure legend Multiscale 4D imaging framework for integrated phenotyping of post‐infarction remodelling. Myocardial infarction triggers dynamic changes across mechanical, haemodynamic and biological axes, progressing from acute injury and inflammation to extracellular matrix remodelling and scar maturation.
Hanzhou Lei, Boris Martinac, Yang Guo
wiley   +1 more source

P2X3 receptor antagonism improves hindlimb blood flow during exercise in a conscious ovine model of hypertensive heart failure with preserved ejection fraction

The Journal of Physiology, EarlyView.
Abstract figure legend A preclinical large‐animal model of hypertensive heart failure with preserved ejection fraction (HFpEF) was used to examine the role of purinergic P2X3 receptor signalling during treadmill exercise. Animals were instrumented with either thoracic cardiac output and coronary flow probes or abdominal renal and hindlimb blood flow ...
Mridula Pachen, Siyi Chen, Joshua W.‐H. Chang, Audrys Pauza, Julia Shanks, Bindu George, Julian Paton, Rohit Ramchandra   +7 more
wiley   +1 more source

Fatty Acid Prof iles of Ram's Sperm after Removing Some Fatty Acid Sources from the Diets and Persistency of Fatty Acids in Sperm [PDF]

International Journal of Fertility and Sterility, 2012
Background Mammalian spermatozoa are characterized by a high proportion of polyunsaturated fatty acids (PUFAs), but reliable data concerning dietary effects on fatty acid (FA) profile in ram's sperm and the persistency of FA in the ration to the FA in
Vahid Esmaeili, Abdolhossein Shahverdi, Ali Reza Alizadeh, Hiva Alipour, Armin Towhidi   +4 more
doaj  

Mechanical Characterization of Cervical Spinal Cord Tissue Under Varied Environmental Conditions

Proceedings in Applied Mathematics and Mechanics, Volume 26, Issue 4, December 2026.
ABSTRACT Identifying material parameters for cervical spinal cord tissue requires an understanding of how testing protocols affect the measured response. We use ovine cervical spinal cord white matter to examine the effects of hydration, temperature, adhesive fixation and repeated loading.
Hanwen Zhang, Bernd Markert
wiley   +1 more source

Adaptive Immunity in Marsupials

Journal of Experimental Zoology Part A: Ecological and Integrative Physiology, Volume 345, Issue 9, Page 913-932, November 2026.
Comparison of the marsupial and eutherian adaptive immune systems. ABSTRACT Marsupials diverged from eutherian mammals 125–160 million years ago. Although evolutionarily distinct, both groups of mammals can produce complex adaptive immune responses to antigens with several key differences.
Cassandra L. Jol, Hayley J. Stannard, Julie M. Old   +2 more
wiley   +1 more source

Isolation and Phylogenetic Analysis of Parapoxvirus orf From Outbreaks in Sheep in the Brazilian Midwest

Zoonoses and Public Health, Volume 73, Issue 7, Page 606-614, November 2026.
ABSTRACT Introduction This study aimed to isolate Parapoxvirus orf and characterize its genetic diversity through phylogenetic analysis in small ruminants from the state of Mato Grosso, Brazil. Methods A total of 103 scab samples were collected from sheep affected by nine contagious ecthyma outbreaks across three different mesoregions of Mato Grosso ...
Phelipe Magalhães Duarte, Maria de Nazaré Santos Ferreira, Amanda Marques Cordeiro, Sérgio Alves do Nascimento, Rita de Cássia Carvalho Maia, José Wilton Pinheiro Junior   +5 more
wiley   +1 more source