Results 91 to 100 of about 1,923,993 (306)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Fundusz sołecki jako forma realizacji zadań gminy przez sołectwa

open access: yesActa Iuris Stetinensis, 2017
The aim of this study is to investigate and present nature of the regulations setting out the rules and procedures of real estate. Legal issues of trade in agricultural property is one of the most important and the most complex issues of agricultural law.
Urszula Głód-van de Sanden
doaj   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

open access: yesMolecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel   +6 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

open access: yesMolecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano   +6 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Choice of ownership structure and firm performance: Evidence from Estonia [PDF]

open access: yes
In this paper we use rich panel data for a representative sample of Estonian enterprises to analyse diverse issues related to the determinants of ownership structures and ownership changes after privatisation.
Derek C. Jones, Niels Mygind, Panu Kalmi
core   +3 more sources

Platform Ownership.. [PDF]

open access: yes
We develop a theoretical framework of trade on a platform on which buyers and sellers interact, and compare the impact of different platform ownership structures.
Nocke, Volker   +2 more
core   +1 more source

Path dependence or convergence? The evolution of corporate ownership around the world [PDF]

open access: yes, 2006
We offer a theory that sheds light on the current debate over whether the form of corporate ownership converges to the Berle-Means image. Our analytical results are threefold. First, legal rules and firm-specific protective arrangements are complementary.
Lim, Steven   +2 more
core   +3 more sources

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

Przemiany w sposobie rozumienia prawa własności. Przejście z ujęcia absolutnego do przyjęcia ograniczonego i prospołecznego charakteru tego prawa

open access: yesActa Iuris Stetinensis, 2016
The article concerns the changes in the content and in the way of understanding of ownership that occurred from the period of antiquity. Initially, it was considered inviolable right of ownership, exclusive and unlimited.
Adam Banaszkiewicz
doaj   +1 more source

Home - About - Disclaimer - Privacy