Results 101 to 110 of about 1,923,993 (306)
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Waste management companies in Europe 2009 [PDF]
, 2010 This paper examines the ownership, employment and finances of the major waste companies in Europe, and recent developments in ...
Hall, David
core
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Conservation Letters, 2019 Biodiversity conservation requires space where conservation measures are implemented for a desired purpose. Setting land aside for conservation has been widely applied, while novel conservation modes (private–public partnerships, private multipurpose ...
Oliver Schöttker, Maria João Santos
doaj +1 more source
More Than an Academic Question: Defining Student Ownership of Intellectual Property Rights [PDF]
, 2018 Intellectual property is increasingly important due to technology’s rapid development. The importance of intellectual property is also reflected within universities as traditional centers of research and expression, where students and faculty are ...
Lozano, Michael A., Saunders, Kurt M
core +1 more source
Molecular Oncology, EarlyView.Translational cancer research and its implementation through competitively selected Comprehensive Cancer Centers across Europe should be the primary policy focus for addressing the increasing cancer burden in Europe and counteract the present main strategy to convert cancer to a chronic disease.
Manuel Heitor +2 more
wiley +1 more source
CONSTITUTIONAL FOUNDATIONS OF THE PROPERTY RIGHTS OF CITIZENS AND ORGANIZATIONS FOR REAL ESTATE
Russian Journal of Economics and Law, 2015 Objective: to develop a comprehensive scientific conception of the constitutional foundations of the property rights of citizens and organizations for real estate.
Z. K. Kondratenko
doaj
A Liberal Enchanted by Socialism? The Issue of Ownership in Neoliberal Doctrine of Ferdinand Zweig
Studia Historiae Oeconomicae, 2020 Ferdinand Zweig, who seems to be forgotten today, was one of the most eminent representatives of the so-called "Cracow School," an influential circle of economists associated with the Jagiellonian University.
Przemysław Pluciński +1 more
doaj
Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity
FEBS Open Bio, EarlyView.Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz +9 more
wiley +1 more source