Results 81 to 90 of about 405,023 (301)

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

open access: yesMolecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel   +6 more
wiley   +1 more source

Taxation and the Evolution of Aggregate Corporate Ownership Concentration [PDF]

open access: yes
Legal rules, politics and behavioral factors have all been emphasized as explanatory factors in analyses of the determinants of the concentration of corporate ownership and stock market participation.
Dhammika Dharmapala   +2 more
core  

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

open access: yesMolecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano   +6 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Konsentrasi Kepernilikan Media dan Ancaman Ruang Publik

open access: yesJSP: Jurnal Ilmu Sosial dan Ilmu Politik, 2008
The trend toward the concentration of media ownership in the hand of few media moguls in many parts of the world has been a subject of criticism. Concentration of media ownership has been one of the main threat to democracy and public sphere.
- Eriyanto
doaj   +1 more source

Asset Pricing with Concentrated Ownership of Capital [PDF]

open access: yesSSRN Electronic Journal, 2011
This paper investigates how concentrated ownership of capital in‡uences the pricing of risky assets in a production economy. The model is designed to approximate the skewed distribution of wealth and income in U.S. data. I show that concentrated ownership significantly magni…es the equity risk premium relative to an otherwise similar ...
openaire   +4 more sources

Diversification and Ownership Concentration [PDF]

open access: yes
We consider a mean-variance general equilibrium economy where the expected returns for controlling and non-controlling shareholders are different because the former are able to divert a fraction of the profits.
Bruno Maria Parigi, Loriana Pelizzon
core  

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