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Contribution of Dietary Oxalate and Oxalate Precursors to Urinary Oxalate Excretion [PDF]

Nutrients, 2020
Kidney stone disease is increasing in prevalence, and the most common stone composition is calcium oxalate. Dietary oxalate intake and endogenous production of oxalate are important in the pathophysiology of calcium oxalate stone disease. The impact of dietary oxalate intake on urinary oxalate excretion and kidney stone disease risk has been assessed ...
Joseph J. Crivelli, Tanecia Mitchell, John Knight, Kyle D. Wood, Dean G. Assimos, Ross P. Holmes, Sonia Fargue   +6 more
openaire   +3 more sources

Oxalate homeostasis

Nature Reviews Nephrology, 2022
Oxalate homeostasis is maintained through a delicate balance between endogenous sources, exogenous supply and excretion from the body. Novel studies have shed light on the essential roles of metabolic pathways, the microbiome, epithelial oxalate transporters, and adequate oxalate excretion to maintain oxalate homeostasis.
Theresa Ermer, Lama Nazzal, Maria Clarissa Tio, Sushrut Waikar, Peter S. Aronson, Felix Knauf   +5 more
openaire   +3 more sources

Expression Analysis of Oxalate Metabolic Pathway Genes Reveals Oxalate Regulation Patterns in Spinach

Molecules, 2018
Spinach (Spinacia oleracea L.) is one of most important leafy vegetables because of its high nutritional value and high oxalate content, which can be toxic with negative effects on human nutrition.
Xiaofeng Cai, Chenhui Ge, Chenxi Xu, Xiaoli Wang, Shui Wang, Quanhua Wang   +5 more
doaj   +2 more sources

Probiotic Oxalate-Degrading Bacteria: New Insight of Environmental Variables and Expression of the oxc and frc Genes on Oxalate Degradation Activity

Foods, 2022
Oxalate, a compound produced by many edible plants and as a terminal metabolite in the liver of mammals, is a toxin that has a detrimental role to human health. Humans and other mammals do possess enzymatic systems to degrade oxalate.
Dina Karamad, Kianoush Khosravi-Darani, Amin Mousavi Khaneghah, Aaron W. Miller   +3 more
doaj   +1 more source

Oxalate in Foods: Extraction Conditions, Analytical Methods, Occurrence, and Health Implications

Foods, 2023
Oxalate is an antinutrient present in a wide range of foods, with plant products, especially green leafy vegetables, being the main sources of dietary oxalates. This compound has been largely associated with hyperoxaluria, kidney stone formation, and, in
Neuza Salgado, M. Silva, M. Figueira, H. Costa, T. Albuquerque   +4 more
semanticscholar   +1 more source

Oxalate-induced apoptosis through ERS-ROS–NF-κB signalling pathway in renal tubular epithelial cell

Molecular Medicine, 2022
Background Kidney stones are composed of approximately 70–80% calcium oxalate. However, the exact mechanism of formation of calcium oxalate kidney stones remains unclear.
Shaoxiong Ming, Jia Tian, Ke Ma, Cheng-bin Pei, Ling Li, Zeyu Wang, Ziyu Fang, Min Liu, Hao Dong, Weijian Li, Jian-Cheng Zeng, Yonghan Peng, Xiaofeng Gao   +12 more
semanticscholar   +1 more source

Pathophysiology and Management of Hyperoxaluria and Oxalate Nephropathy: A Review.

American Journal of Kidney Diseases, 2021
Hyperoxaluria results from either inherited disorders of glyoxylate metabolism leading to hepatic oxalate overproduction (primary hyperoxaluria), or increased intestinal oxalate absorption (secondary hyperoxaluria).
N. Demoulin, S. Aydın, V. Gillion, J. Morelle, M. Jadoul   +4 more
semanticscholar   +1 more source

Oxalate Activates Autophagy to Induce Ferroptosis of Renal Tubular Epithelial Cells and Participates in the Formation of Kidney Stones

Oxidative Medicine and Cellular Longevity, 2021
Renal tubular epithelial cell damage is the basis for the formation of kidney stones. Oxalate can induce human proximal tubular (HK-2) cells to undergo autophagy and ferroptosis.
Qianlin Song, W. Liao, Xin Chen, Ziqi He, De Li, Bin Li, Junwei Liu, Lang Liu, Yunhe Xiong, Chao Song, Sixing Yang   +10 more
semanticscholar   +1 more source

Two One-Dimensional Copper-Oxalate Frameworks with the Jahn–Teller Effect: [(CH₃)₃NH]₂[Cu(μ-C₂O₄)(C₂O₄)]·2.5H₂O (I) and [(C₂H₅)₃NH]₂[Cu(μ-C₂O₄)(C₂O₄)]·H₂O (II)

Magnetochemistry, 2023
Two one-dimensional oxalate-bridged Cu(II) ammonium salts, [(CH3)3NH]2[Cu(μ-C2O4)(C2O4)]·2.5H2O (I) and [(C2H5)3NH]2[Cu(μ-C2O4)(C2O4)]·H2O (II) were obtained and characterized.
Bin Zhang, Yan Zhang, Zheming Wang, Yang Sun, Tongling Liang, Mei Liu, Daoben Zhu   +6 more
doaj   +1 more source

Forty Years of Oxalobacter formigenes, a Gutsy Oxalate-Degrading Specialist

Applied and Environmental Microbiology, 2021
Oxalobacter formigenes, a unique anaerobic bacterium that relies solely on oxalate for growth, is a key oxalate-degrading bacterium in the mammalian intestinal tract. Degradation of oxalate in the gut by O.
S. Daniel, L. Moradi, H. Paiste, Kyle D. Wood, D. Assimos, R. Holmes, Lama Nazzal, M. Hatch, J. Knight   +8 more
semanticscholar   +1 more source