USP45 stabilizes CFTR through deubiquitination, thereby activating PMCA, which inhibits calcium/chloride overload and mitochondrial oxidative stress in senescent cardiomyocytes, ultimately alleviating cardiomyocyte senescence. ABSTRACT Cardiomyocyte senescence drives cardiovascular disease, underscoring the need to define its molecular mechanisms.
Chun Chen +10 more
wiley +1 more source
Overexpression of SIRT3 ameliorates calcium oxalate crystal-induced renal necroptosis by suppressing the TNF-α/RIPK3/P-MLKL pathway. [PDF]
Zhang S +9 more
europepmc +1 more source
Increasing Dietary Potassium Enhances Urine Production and Reduces Risk of Calcium Oxalate Stone Formation in Senior Cats. [PDF]
Hall JA, Yu S, Toillion AR, Jewell DE.
europepmc +1 more source
Characterizing the causes and consequences of calcium oxalate crystal presence in Vitis riparia. [PDF]
Graham CDK, Molino S, Yerks AL, Weber M.
europepmc +1 more source
Novel AAV843 Vector-Mediated Gene Replacement Therapy Rescues Primary Hyperoxaluria Type I in Mice. [PDF]
Zhang J +9 more
europepmc +1 more source
Scalable electrochemical CO<sub>2</sub> reduction to oxalate in a continuous flow reactor. [PDF]
Dionisio D +5 more
europepmc +1 more source
Urinary biomarkers of urolithiasis risk in Crohn's disease: hyperoxaluria, hypocitraturia, and hypomagnesuria in patients with and without ileocolic resection. [PDF]
Navratil V +6 more
europepmc +1 more source
Contribution of dietary oxalate to urinary oxalate excretion [PDF]
The amount of oxalate excreted in urine has a significant impact on calcium oxalate supersaturation and stone formation. Dietary oxalate is believed to make only a minor (10 to 20%) contribution to the amount of oxalate excreted in urine, but the validity of the experimental observations that support this conclusion can be questioned.
Ross P Holmes +2 more
exaly +5 more sources
Related searches:
Oxalate homeostasis is maintained through a delicate balance between endogenous sources, exogenous supply and excretion from the body. Novel studies have shed light on the essential roles of metabolic pathways, the microbiome, epithelial oxalate transporters, and adequate oxalate excretion to maintain oxalate homeostasis.
Theresa Ermer +5 more
openaire +2 more sources
Relative effect of urinary calcium and oxalate on saturation of calcium oxalate Rapid Communication [PDF]
Relative effect of urinary calcium and oxalate on saturation of calcium oxalate.BackgroundThe study compared the effect of urinary calcium with that of oxalate on urinary saturation [relative saturation ratio (RSR)] of calcium oxalate.MethodsA ...
Charles Y C Pak +2 more
exaly +2 more sources

