Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
Microbial aspects of anaerobic methane oxidation with sulfate as electron acceptor [PDF]
, 2009 Anaerobic oxidation of methane (AOM) is an important methane sink in the ocean but the microbes responsible for AOM are as yet resilient to cultivation.
Jagersma, C.G.
core
The depth specific significiance, relative abundance and phylogeography of anaerobic ammonium oxidation (anammox) in marine and estuarine sediments [PDF]
, 2009 PhDThe availability of fixed forms of nitrogen is critical to the regulation of primary production. Until recently, denitrification (the sequential reduction of NO3 -, through NO2 - , to di-nitrogen gas) was recognised as the only significant pathway
Rooks, Christine
core +4 more sources
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Reduction of Parasitic Capacitance in Vertical MOSFETs by Spacer Local Oxidation
, 2003 Application of double gate or surround-gate vertical metal oxide semiconductor field effect transistors (MOSFETs) is hindered by the parasitic overlap capacitance associated with their oayout, which is considerably larger than for a lateral MOSFET on the
Ashburn, Peter +7 more
core +1 more source
Indirect Spectrophotometric Determination of Niclosamide in Pharmaceutical Preparations [PDF]
مجلة التربية والعلم, 2018 A simple and sensitive indirect spectrophotometric method is developed for the determination of niclosamide in pharmaceutical preparations. The method is based on the oxidation of reduced form of niclosamide with iron ( III ) in acidic medium, then the ...
Nabeel S. Othman, Saad H. Sultan
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Biotechnological aspects of anaerobic oxidation of methane coupled to sulfate reduction [PDF]
, 2009 Sulfate reduction (SR) can be used for the removal and recovery of metals and oxidized sulfur compounds from waste streams. Sulfate-reducing bacteria reduce oxidized sulfur compounds to sulfide.
Meulepas, R.J.W.
core
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
mBio, 2017 This study demonstrates that the deltaproteobacterium Desulfurivibrio alkaliphilus can grow chemolithotrophically by coupling sulfide oxidation to the dissimilatory reduction of nitrate and nitrite to ammonium.
Casper Thorup +4 more
doaj +1 more source