Results 41 to 50 of about 788,539 (257)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Characterization of nano-oxide layers fabricated by ion beam oxidation [PDF]

, 2002
In this paper, a remote O2 ion source is used for the formation of nano-oxide layers. The oxidation efficiency was measured in CoFe-oxide films, and a decrease of the oxide layer with the pan angle and the oxidation pressure is observed.
Susana Cardoso, Snoeck, E., Soares, J. C., Haohua Li, Etienne Snoeck, Peng Wei, José C. Soares, Zongzhi Zhang, Ricardo Ferreira, Ferreira, R., Paulo P. Freitas, Cardoso, Susana, Xavier Batlle, Peng, Wei, Batlle Gelabert, Xavier, Freitas, P. P.   +15 more
core   +1 more source

Paraoxonase Role in Human Neurodegenerative Diseases

Antioxidants, 2020
The human body has biological redox systems capable of preventing or mitigating the damage caused by increased oxidative stress throughout life. One of them are the paraoxonase (PON) enzymes.
Cadiele Oliana Reichert, Debora Levy, Sergio P. Bydlowski   +2 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Real-time quantitative analysis of volatile products generated during solid-state polypropylene thermal oxidation [PDF]

, 2013
Analysis of volatile organic compounds (VOCs) during PP thermal oxidation under three oxygen partial pressures (0%, 21% and 100% of atmospheric pressure) at 140 C was performed by proton transfer reaction coupled with Fourier transform ion cyclotron ...
LEPROVOST, Julien, COLIN, Xavier, DESNOUX, Eric, MESTDAGH, Helene, FRANCOIS-HEUDE, Alexandre, RICHAUD, Emmanuel, HENINGER, Michel   +6 more
core   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Health status, lifestyle and quality of life in older adults of rural and urban areas of Tarragona province (Catalonia, Spain): a cross-sectional descriptive study

BMC Public Health
Background People over 60 years old represent 26.5% of the world’s population, and enhancing health emerges as an opportunity. Thus, this study aims to describe and compare the health status (sarcopenia parameters), lifestyles, quality of life, and ...
C. Jiménez-Ten Hoevel, J. Queral, M. Besora-Moreno, L. Tarro, A. Sospedra-Senar, J. Tomàs-Piqueras, C. Sepúlveda, R.M. Valls, A. Pedret, R. Solà, E. Llauradó   +10 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

A workplace intervention to reduce alcohol and drug consumption: a nonrandomized single-group study

BMC Public Health, 2018
Background The consumption of alcohol and other drugs causes social and health problems in industrialized societies. Furthermore, alcohol and drug consumption in the workplace is associated with work accidents, absenteeism and low productivity.
Montse Gómez-Recasens, Silvana Alfaro-Barrio, Lucia Tarro, Elisabet Llauradó, Rosa Solà   +4 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source