Results 61 to 70 of about 1,412,233 (318)

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Participatory Research in Clinical Studies: An Innovative Approach to Co‐creating Nutritional and Physical Activity Recommendations for Older Adults With Sarcopenia (FOOP‐Sarc Project)

Health Expectations
Background Participating in co‐creation processes can improve the knowledge, satisfaction and healthcare outcomes of volunteers. However, this methodology is still underused in nutritional clinical studies. Objective This study aimed to use participatory
Maria Besora‐Moreno, Cristina Sepúlveda, Judit Queral, Claudia Jiménez‐ten Hoevel, Anna Pedret, Lucia Tarro, Rosa M. Valls, Rosa Solà, Elisabet Llauradó   +8 more
doaj   +1 more source

The Effects of the Combination of Buckwheat D-Fagomine and Fish Omega-3 Fatty Acids on Oxidative Stress and Related Risk Factors in Pre-Obese Rats

Foods, 2021
The combined supplementation of buckwheat D-fagomine (FG) and fish omega-3 polyunsaturated fatty acids (ω-3 PUFA) attenuates the development of insulin resistance in rats fed a high-fat (HF) diet.
Bernat Miralles-Pérez, Maria Rosa Nogués, Vanessa Sánchez-Martos, Núria Taltavull, Lucía Méndez, Isabel Medina, Sara Ramos-Romero, Josep L. Torres, Marta Romeu   +8 more
doaj   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Effects of Oxysterols on Immune Cells and Related Diseases

Cells, 2022
Oxysterols are the products of cholesterol oxidation. They have a wide range of effects on several cells, organs, and systems in the body. Oxysterols also have an influence on the physiology of the immune system, from immune cell maturation and migration
Fábio Alessandro de Freitas, Débora Levy, Cadiele Oliana Reichert, Edecio Cunha-Neto, Jorge Kalil, Sérgio Paulo Bydlowski   +5 more
doaj   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Numerical simulation of cyclic oxidation kinetics with automatic fitting of experimental data [PDF]

, 2007
This paper proposes a model, based on a Monte Carlo method, to assess cyclic oxidation tests. The numerical code fits automatically the experimental net mass change curves.
Poquillon, Dominique, Sureau, S., Monceau, Daniel, Sureau, Sandrine   +3 more
core   +1 more source

Identification of a potent palladium-aryldiphosphine catalytic system for high-performance carbonylation of alkenes

Nature Communications
The development of stable and efficient ligands is of vital significance to enhance the catalytic performance of carbonylation reactions of alkenes.
Kang Zhao, Hongli Wang, Teng Li, Shujuan Liu, Enrico Benassi, Xiao Li, Yao Yao, Xiaojun Wang, Xinjiang Cui, Feng Shi   +9 more
doaj   +1 more source

Polyoxometalate-Based Catalysts for CO₂ Conversion

Molecules, 2019
Polyoxometalates (POMs) are a diverse class of anionic metal-oxo clusters with intriguing chemical and physical properties. Owing to unrivaled versatility and structural variation, POMs have been extensively utilized for catalysis for a plethora of ...
Yanwei Cao, Qiongyao Chen, Chaoren Shen, Lin He   +3 more
doaj   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source