Results 41 to 50 of about 151,251 (265)

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

Kinetics for Oxidation of Squalene.

KAGAKU KOGAKU RONBUNSHU, 2000
スクアレンの酸化反応速度を気泡塔型反応器を用いて測定した. 酸化反応は, 過酸化物の生成速度が緩やかな誘導期とその生成速度が自触媒的に増加する加速期の二つの段階によって進行することがわかった. 過酸化物濃度は加速期の後半で最大となり, その後緩やかに減少した. 紫外/可視吸収および化学発光検出器を備えた高速液体クロマトグラフィーを用いてスクアレンおよび6種の過酸化物生成挙動を確認した. 酸化反応によって生成した過酸化物は高温で容易に分解され, 分解生成物の主成分はカルボニル化合物であることがわかった. 実験結果を脂質ラジカルを考慮した連鎖反応モデルに基づいて解析し, 酸化速度式を導出した.
SUN, WEI, SHIOMORI, KOICHIRO, KAWANO, YOSHINOBU, HATATE, YASUO   +3 more
openaire   +2 more sources

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Neural NetworkModeling of Oxidation Kinetics in Air of Steel-T21 Alloy Coated by Simultaneous Germanium-Doped Aluminizing-Silicon zing Process [PDF]

Engineering and Technology Journal, 2013
In this work a pack cementation of germanium-doped aluminum and silicon coatings on low alloy steel type-T21 has been applied. This gives significant improvement in the oxidation.
Abbas Khammas, Mohanned M. H.AL-Khafaji
doaj   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Spectroscopic and Kinetic Characterization of Peroxidase-Like π-Cation Radical Pinch-Porphyrin-Iron(III) Reaction Intermediate Models of Peroxidase Enzymes

Molecules, 2016
The spectroscopic and kinetic characterization of two intermediates from the H2O2 oxidation of three dimethyl ester [(proto), (meso), (deuteroporphyrinato) (picdien)]Fe(III) complexes ([FePPPic], [FeMPPic] and [FeDPPic], respectively) pinch-porphyrin ...
Samuel Hernández Anzaldo, Uriel Arroyo Abad, Armando León García, Daniel Ramírez Rosales, Rafael Zamorano Ulloa, Yasmi Reyes Ortega   +5 more
doaj   +1 more source

Fat oxidation, hormonal and plasma metabolite kinetics during a submaximal incremental test in lean and obese adults. [PDF]

PLoS ONE, 2014
This study aimed to compare fat oxidation, hormonal and plasma metabolite kinetics during exercise in lean (L) and obese (O) men. Sixteen L and 16 O men [Body Mass Index (BMI): 22.9 ± 0.3 and 39.0 ± 1.4 kg · m(-2)] performed a submaximal incremental test
Stefano Lanzi, Franco Codecasa, Mauro Cornacchia, Sabrina Maestrini, Alberto Salvadori, Amelia Brunani, Davide Malatesta   +6 more
doaj   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

Oxidation and Corrosion Mechanism of Steel Alloys and Inconel 600 Alloy in Liquid–Lead-Bismuth Eutectic [PDF]

Engineering and Technology Journal, 2008
The alloys used in this study were two types pf stainless steels (304SS and316 SS) , low alloy steel (Type T22-ASTM) and Inconel 600 alloy `(nickelbasesuperalloy).
Ahmed Moosa
doaj   +1 more source