Results 51 to 60 of about 101,920 (247)

Ynol Ethers: Synthesis and Reactivity

CHIMIA, 2016
Ynol ethers are highly valuable substrates offering a wide range of reactivity. These highly electron-rich heterosubstitued alkynes can be of great synthetic potential.
Charlie Verrier, Sébastien Carret, Jean-François Poisson   +2 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Cr2AlC and metals reactivity: Sintering and oxidation

Open Ceramics
Cr2AlC-20 wt% (Sn; Cu; Co; Fe; Ag) powder mixtures were hot isostatically pressed at 1000 °C for 4 h under 150 MPa to investigate the possible alloying behaviour of the metals with the MAX phase. The as-synthesized bulk materials were further oxidized at
A. Zuber, V. Gauthier-Brunet, S. Dubois
doaj   +1 more source

Redox Signaling by Reactive Electrophiles and Oxidants [PDF]

Chemical Reviews, 2018
The concept of cell signaling in the context of nonenzyme-assisted protein modifications by reactive electrophilic and oxidative species, broadly known as redox signaling, is a uniquely complex topic that has been approached from numerous different and multidisciplinary angles.
Saba Parvez, Marcus J. C. Long, Jesse R. Poganik, Yimon Aye   +3 more
openaire   +2 more sources

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Summertime OH reactivity from a receptor coastal site in the Mediterranean Basin [PDF]

Atmospheric Chemistry and Physics, 2017
Total hydroxyl radical (OH) reactivity, the total loss frequency of the hydroxyl radical in ambient air, provides the total loading of OH reactants in air.
N. Zannoni, N. Zannoni, V. Gros, R. Sarda Esteve, C. Kalogridis, C. Kalogridis, V. Michoud, V. Michoud, S. Dusanter, S. Sauvage, N. Locoge, A. Colomb, B. Bonsang   +12 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Oxidation of amino acids by peracetic acid: Reaction kinetics, pathways and theoretical calculations

Water Research X, 2018
Peracetic acid (PAA) is a sanitizer with increasing use in food, medical and water treatment industries. Amino acids are important components in targeted foods for PAA treatment and ubiquitous in natural waterbodies and wastewater effluents as the ...
Penghui Du, Wen Liu, Hongbin Cao, He Zhao, Ching-Hua Huang   +4 more
doaj   +1 more source

REACTIVITY STUDIES OF URANIUM OXIDES [PDF]

, 1957
One amorphous and three crystalline polymorphic modlfications of UO/sub 3/ have been prepared by pyrolysis of uranyl nitrate hexahydrate. The hydration reactivity of UO/sub 3/ appears to be a function of its residual N content which is, in turn, dependent on the method, time, and temperatuee of denitration.
Vaughan, D.A., Bridge, J.R., Schwartz, C.M.   +2 more
openaire   +2 more sources